PPP1R16B and CDK5RAP1

Data Source:
BioGRID (biochemical)

		PPP1R16B	CDK5RAP1
Description		protein phosphatase 1 regulatory subunit 16B	CDK5 regulatory subunit associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm	Cellular_component Mitochondrion Cytosol
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity	Protein Kinase Binding N6-isopentenyladenosine Methylthiotransferase Activity Protein-containing Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Filopodium Assembly Establishment Of Endothelial Barrier Negative Regulation Of Peptidyl-serine Dephosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	Brain Development TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Fidelity Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification
Pathways
Drugs
Diseases
GWAS		Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)	Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412) Mean corpuscular volume ( 32888494)
Interacting Genes		37 interacting genes: ATPAF2 CDCA7L CEP55 CEP70 CRX DVL2 DVL3 FAM83A FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 IKZF3 KCTD9 MAGOH MISP NEFL PATZ1 PHC2 PLEKHN1 PPP1CA PPP1CB RBPMS RFC5 SCNM1 SF3B4 SHC3 TACO1 TADA2A TASOR2 TFIP11 TLE5 TXN2 ZNF410 ZNF564	4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5
Entrez ID		26051	51654
HPRD ID		15168	12189
Ensembl ID		ENSG00000101445	ENSG00000101391
Uniprot IDs		Q96T49	A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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