RPAP1 and POLR2B

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		RPAP1	POLR2B
Description		RNA polymerase II associated protein 1	RNA polymerase II subunit B
Image		No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus	DNA-directed RNA Polymerase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity	DNA Binding Chromatin Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II	RNA-templated Transcription DNA-templated Transcription Transcription By RNA Polymerase II
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		A body shape index ( 34021172) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lung function (FEV1/FVC) ( 30175238 30804560) Medication use (drugs used in diabetes) ( 31015401) Peak expiratory flow ( 30804560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)
Interacting Genes		7 interacting genes: GPN1 POLR2B POLR2C POLR2G POLR2L POT1 TERF2IP	19 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 OTUD5 POLR2C POLR2D POLR2H POLR2L PTEN RPAP1 SNAR-B2 SUB1 ZSCAN1
Entrez ID		26015	5431
HPRD ID		11522	15943
Ensembl ID		ENSG00000103932	ENSG00000047315
Uniprot IDs		A8K2F9 Q9BWH6	B4DH29 B4DHJ3 C9J2Y9 P30876
PDB IDs			5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process DNA-directed RNA Polymerase Activity Macromolecule Biosynthetic Process Shelterin Complex Transcription By RNA Polymerase II Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping DNA-templated Transcription Nucleic Acid Metabolic Process Nucleoplasm Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Regulation Of Telomere Maintenance Nucleus Ribonucleoside Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Metabolic Process Negative Regulation Of DNA Metabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Organization Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding 5'-3' RNA Polymerase Activity Macromolecule Metabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere DEAD/H-box RNA Helicase Binding	DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process Nucleus DNA-templated Transcription Transcription By RNA Polymerase II Transcription Factor TFIIK Complex DNA-directed RNA Polymerase Activity CAK-ERCC2 Complex RNA Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm RNA Polymerase II Promoter Clearance Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex DNA-templated Transcription Initiation Transcription Factor TFIIH Holo Complex RNA Polymerase I Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase III Complex Spindle Pole Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein-containing Complex Regulation Of Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Elongation By RNA Polymerase II RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Type I Interferon Production Male Germ Cell Nucleus DNA-templated Transcription Elongation Negative Regulation Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Stabilization CD4-positive, Alpha-beta T Cell Activation RNA Polymerase Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity TFIIF-class Transcription Factor Complex Binding Negative Regulation Of Osteoblast Differentiation
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