TKFC and TIMM10

		TKFC	TIMM10
Description		triokinase and FMN cyclase	translocase of inner mitochondrial membrane 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Glycerone Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Lyase Activity FAD-AMP Lyase (cyclizing) Activity Metal Ion Binding Triokinase Activity	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol Catabolic Process Negative Regulation Of MDA-5 Signaling Pathway Regulation Of Innate Immune Response Carbohydrate Phosphorylation Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Fructose catabolism SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS			Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		2 interacting genes: SDCBP TIMM10	8 interacting genes: - CNTF CREB3 DAGLA HAGH TBC1D21 TKFC ZNF655
Entrez ID		26007	26519
HPRD ID		13180	03768
Ensembl ID		ENSG00000149476	ENSG00000134809
Uniprot IDs		A0A140VJH7 Q3LXA3	P62072
PDB IDs			2BSK 7CGP
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Membrane Protein Targeting Interleukin-5 Receptor Complex Interleukin-5 Receptor Binding Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Extracellular Exosome Assembly Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex Localization Within Membrane Substrate-dependent Cell Migration, Cell Extension Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Membrane Insertase Activity TIM23 Mitochondrial Import Inner Membrane Translocase Complex Regulation Of Exosomal Secretion Protein Insertion Into Mitochondrial Inner Membrane Cytoskeletal Anchor Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Establishment Of Protein Localization To Mitochondrial Membrane Protein Targeting To Mitochondrion Protein Insertion Into Mitochondrial Membrane Frizzled Binding Inner Mitochondrial Membrane Organization Protein Sequestering Activity Establishment Of Protein Localization	Aldehyde Metabolic Process Positive Regulation Of Deacetylase Activity Glycerone Kinase Activity Triokinase Activity FAD-AMP Lyase (cyclizing) Activity Retrograde Trans-synaptic Signaling By Endocannabinoid Monoacylglycerol Biosynthetic Process Cannabinoid Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Metabolic Process Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione CCR1 Chemokine Receptor Binding Release From Viral Latency Glycerol Catabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of MDA-5 Signaling Pathway Sperm Mitochondrial Sheath Assembly Varicosity Muscle Organ Morphogenesis Lipoprotein Lipase Activity Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation CAMP Response Element Binding Protein Binding Plasma Membrane To Endosome Transport Monoacylglycerol Lipase Activity Glyceraldehyde-3-phosphate Metabolic Process
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