CLIP3 and TNFRSF21

Number of citations of the paper that reports this interaction (PubMedID 22297296)
39

Data Source:
BioGRID (two hybrid)

		CLIP3	TNFRSF21
Description		CAP-Gly domain containing linker protein 3	TNF receptor superfamily member 21
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cell Cortex Membrane Early Endosome Membrane Trans-Golgi Network Membrane Microtubule Plus-end Membrane Raft Recycling Endosome Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding Ganglioside Binding Microtubule Plus-end Binding	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of D-glucose Transmembrane Transport Peptidyl-L-cysteine S-palmitoylation Negative Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Apoptotic Process Membrane Biogenesis Fat Cell Differentiation Positive Regulation Of Endocytosis Protein Transport Along Microtubule Positive Regulation Of Protein Localization To Plasma Membrane	B Cell Apoptotic Process Adaptive Immune Response Immune System Process Apoptotic Process Humoral Immune Response Signal Transduction Axonal Fasciculation Negative Regulation Of B Cell Proliferation Negative Regulation Of Myelination Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of T Cell Proliferation Myelination Regulation Of Oligodendrocyte Differentiation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Cellular Response To Tumor Necrosis Factor Oligodendrocyte Apoptotic Process
Pathways		Regulation of TNFR1 signaling	PPARA activates gene expression
Drugs
Diseases
GWAS			Panic disorder ( 19165232) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122)
Interacting Genes		8 interacting genes: AKT1 AKT2 CEP83 FBXO7 GOLGA2 TLE5 TNFRSF1A TNFRSF21	9 interacting genes: CLIP3 MATR3 MMP14 NSD1 PTK7 SGTA STX11 TRADD WASH2P
Entrez ID		25999	27242
HPRD ID		09572	05759
Ensembl ID		ENSG00000105270	ENSG00000146072
Uniprot IDs		Q96DZ5	O75509
PDB IDs		2CP0	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Polysaccharide Biosynthetic Process Protein Localization To Plasma Membrane Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Lymphocyte Apoptotic Process Protein Localization To Cell Periphery Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Negative Regulation Of Lipid Transport Regulation Of Glycogen Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Myelination Regulation Of Programmed Cell Death Positive Regulation Of Glucose Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Translational Initiation Leukocyte Apoptotic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of D-glucose Import Protein Localization To Membrane Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Establishment Of Protein Localization To Mitochondrion Apoptotic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Programmed Cell Death Intracellular Protein Localization Regulation Of TRNA Methylation Cellular Response To High Light Intensity	Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cardiac Septum Development Ventricular Septum Development Ganglioside Binding
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