PTPN23 and NOTCH2NLA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PTPN23	NOTCH2NLA
Description		protein tyrosine phosphatase non-receptor type 23	notch 2 N-terminal like A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Cilium Nuclear Body Cytoplasmic Vesicle Centriolar Satellite Ciliary Basal Body Cell Projection Extracellular Exosome	Extracellular Region Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Projection Organization Endocytic Recycling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Early Endosome To Late Endosome Transport Cilium Assembly Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway
Pathways		Interleukin-37 signaling	NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Expression of NOTCH2NL genes
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Refractive error ( 32231278) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		12 interacting genes: ALG2 BICD1 CEP19 CEP55 CHMP4B DDX24 LRRK2 NOTCH2NLA PSMA3 TRIM27 UBAP1 WDR4	361 interacting genes: ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADCK5 AGXT ALDH16A1 ALDH3B1 ALPI ALPP ANKS1A AQP1 AQP5 ARID3A ASPSCR1 ATG9A ATP5F1D BCAM BCL6B BLCAP BMP7 BRME1 C11orf87 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CELF5 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A CNNM3 COL8A1 CRACR2A CRCT1 CREB5 CRH CRY2 CSF1 CST2 CST9L CTNNBIP1 CTSG CTSZ CXCL16 CXCL5 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGCR6 DGKQ DHRS1 DMRT3 DNAL4 DOCK2 DRD5 EFNA3 EIF4E2 ELANE EMC7 EPHB6 ESR2 F10 FAAH FADS2 FAM124B FAM221A FAM74A4 FAM90A1 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 FTHL17 FZD10 GABRD GARIN5B GARIN6 GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IGSF8 IL10 IL2RG INO80B INPP5D INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KIF1A KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LIN7A LINC00526 LINC00656 LMNTD2 LMO2 LNX1 LONRF3 LRCH4 LRFN4 LYVE1 MACO1 MAPKBP1 MARK4 MATN3 MELTF MOS MRGBP MRPL40 MTA1 MVP MXD3 MXI1 MYO15B MYPOP NAB2 NAXD NECTIN2 NECTIN3 NEDD9 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NTM NTN4 NUBP2 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCED1A PCED1B PCSK5 PDE9A PGAP6 PGLS PHLDA1 PID1 PIGS PLEKHN1 PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRF1 PRKAA2 PRPF31 PRPS2 PRR19 PRR35 PSMA1 PSMG2 PTGER3 PTK7 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RASD1 RCHY1 RECK RET RGL2 RNF111 RPS19BP1 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA3B SEMA4C SHANK3 SHFL SLC22A23 SLC22A5 SLC23A1 SLC25A10 SLC25A6 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA24 SPATA31J1 SPATA8 SPG7 SPINK2 SPPL2C SPRY1 STAC STK16 TAPBPL TBC1D10C TBC1D16 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEFF2 TMEM150A TMEM231 TMEM41A TMIE TNIP3 TNK2 TNP2 TNS2 TRAPPC14 TRIM27 TRIM42 TROAP TRPV6 TSPAN4 TTPA TXNDC5 UBQLN4 UTP23 UXT VASN WDR25 WT1-AS XCL2 YIPF3 ZDHHC1 ZFTRAF1 ZFYVE21 ZNF124 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF688 ZNF786 ZNF837
Entrez ID		25930	388677
HPRD ID		05959	14833
Ensembl ID		ENSG00000076201	ENSG00000264343
Uniprot IDs		B4DST5 Q9H3S7	A0A8I5KR58 Q7Z3S9
PDB IDs		3RAU 5CRU 5CRV 5LM1 5LM2 5MJY 5MJZ 5MK0 5MK1 5MK2 5MK3
Enriched GO Terms of Interacting Partners?		Organelle Localization Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Mitotic Cytokinetic Process Midbody Abscission Late Endosome To Vacuole Transport Vesicle-mediated Transport Intracellular Transport Endosomal Transport Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Cytokinetic Process Mitotic Metaphase Chromosome Alignment Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Organelle Assembly Endosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Mitotic Cytokinesis Chromosome Localization Alpha-1,3-mannosyltransferase Activity Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Endosome Organization Establishment Of Protein Localization To Organelle Proteinase Activated Receptor Binding Negative Regulation Of Catabolic Process TRNA (guanine-N7)-methylation Cytoskeleton-dependent Cytokinesis Nucleus Organization Regulation Of Notch Signaling Pathway Positive Regulation Of Protein Autoubiquitination Response To Curcumin	Intermediate Filament Keratin Filament Protein Binding Keratinization Epidermis Development Hair Cycle Identical Protein Binding Carbon Dioxide Transport Nitric Oxide Transport Purinergic Nucleotide Receptor Signaling Pathway
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