THUMPD3 and TRMT112

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical)

		THUMPD3	TRMT112
Description		THUMP domain 3 tRNA guanosine methyltransferase	tRNA methyltransferase activator subunit 11-2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol TRNA Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex TRNA (m2G10) Methyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity TRNA (guanine) Methyltransferase Activity Transferase Activity TRNA (guanine(6)-N2)-methyltransferase Activity TRNA (guanine(7)-N2)-methyltransferase Activity	Protein Binding Protein Methyltransferase Activity Protein Heterodimerization Activity TRNA Methyltransferase Activator Activity
	Biological Process	RNA Processing TRNA Processing TRNA Methylation Methylation	Maturation Of LSU-rRNA RRNA Processing Peptidyl-glutamine Methylation TRNA Methylation Maturation Of SSU-rRNA RRNA Methylation Transcription Initiation-coupled Chromatin Remodeling RRNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing
Pathways			Methylation tRNA modification in the nucleus and cytosol rRNA modification in the nucleus and cytosol Eukaryotic Translation Termination
Drugs
Diseases
GWAS			Crohn's disease ( 28067908) Hematocrit ( 32888494) Vitiligo ( 27723757)
Interacting Genes		2 interacting genes: LSM8 TRMT112	5 interacting genes: MEOX2 METTL5 PAX6 THUMPD3 TMEM216
Entrez ID		25917	51504
HPRD ID		15507	13705
Ensembl ID		ENSG00000134077	ENSG00000173113
Uniprot IDs		Q9BV44	Q9UI30
PDB IDs			6G4W 6H1D 6H1E 6H2U 6H2V 6K0X 6KHS 6KMR 6KMS 6PED 7WTS 7WTT 7WTU 7WTV 7WTW 8CNC 8QDG 8QDI
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamine Methylation TRNA Methyltransferase Activator Activity RRNA (guanine-N7)-methylation TRNA (m2G10) Methyltransferase Complex RNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing RRNA Base Methylation Lsm2-8 Complex U6 SnRNP Protein Methyltransferase Activity Regulation Of RRNA Processing U6 SnRNA Binding Precatalytic Spliceosome RNA Processing RRNA Methylation Maturation Of LSU-rRNA RRNA Modification Protein Methylation TRNA Methylation Maturation Of SSU-rRNA U4/U6 X U5 Tri-snRNP Complex Transcription Initiation-coupled Chromatin Remodeling U2-type Precatalytic Spliceosome Positive Regulation Of Gene Expression, Epigenetic RNA Metabolic Process RNA Methylation TRNA Modification Macromolecule Methylation Nucleic Acid Metabolic Process TRNA Processing	Forebrain-midbrain Boundary Formation Pancreatic A Cell Development TRNA (guanine(7)-N2)-methyltransferase Activity RNA Methylation TRNA (guanine(6)-N2)-methyltransferase Activity Macromolecule Methylation Somite Specification Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Habenula Development Oligodendrocyte Cell Fate Specification Pallium Development Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization TRNA Methyltransferase Complex RNA Modification Methyltransferase Activity TRNA (guanine) Methyltransferase Activity Methylation RRNA (adenine-N6-)-methyltransferase Activity Formation Of Anatomical Boundary Glial Cell Fate Specification Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis HMG Box Domain Binding Co-SMAD Binding MKS Complex Regulation Of Timing Of Cell Differentiation Negative Regulation Of Neuroblast Proliferation Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Segment Specification Somite Development RNA Metabolic Process Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Core Promoter Sequence-specific DNA Binding S-adenosyl-L-methionine Binding RRNA Methylation Sequence-specific DNA Binding Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation
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