ZNF473 and DHX57

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZNF473	DHX57
Description		zinc finger protein 473	DExH-box helicase 57
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cajal Body
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding RNA Polymerase Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA 3'-end Processing By Stem-loop Binding And Cleavage	Positive Regulation Of Translation
Pathways		SLBP independent Processing of Histone Pre-mRNAs Generic Transcription Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		23 interacting genes: AEN APP CLK2 CLK3 DHX57 GPATCH2L KRTAP10-10 KRTAP10-8 KRTAP10-9 LSM11 NUP62 PRPF31 RBM10 RNPS1 SLBP TRIM41 ZNF202 ZNF250 ZNF408 ZNF497 ZNF792 ZNF837 ZSCAN12	27 interacting genes: CARD10 CBX2 CEP44 CXCR4 EIF4ENIF1 HNRNPLL KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP9-4 NAA10 PCGF5 PLAGL2 RBMY1A1 RSPO4 ZNF473 ZNF587 ZNF837
Entrez ID		25888	90957
HPRD ID		11721	09919
Ensembl ID		ENSG00000142528	ENSG00000163214
Uniprot IDs		B4DY71 F8WEC7 Q8WTR7	Q6P158
PDB IDs		2EMB 2EMC 2EME 2EOU 2EOX 2EOY 2EOZ 2YRH 2YRJ 2YSV 2YTD 2YTE 2YTT 2YU5 9AZI
Enriched GO Terms of Interacting Partners?		Identical Protein Binding PTB Domain Binding Nucleus MRNA 3'-end Processing By Stem-loop Binding And Cleavage Histone Pre-mRNA 3'end Processing Complex Regulation Of RNA Splicing Zinc Ion Binding Nuclear Speck RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding MRNA Processing Keratin Filament Negative Regulation Of MRNA Splicing, Via Spliceosome Histone MRNA Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Gene Expression Positive Regulation Of Toll Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity RNA Processing MRNA 3'-end Processing MRNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Negative Regulation Of RNA Splicing Ribonucleoprotein Complex Localization Intermediate Filament Ribonucleoprotein Complex	Keratin Filament Intermediate Filament
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