WHRN and HEMGN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WHRN	HEMGN
Description		whirlin	hemogen
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cilium Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Bundle Stereocilium Tip Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Establishment Of Localization In Cell Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance	Cell Differentiation Regulation Of Osteoblast Differentiation
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Deafness, autosomal recessive Usher syndrome (US)
GWAS			Alopecia areata ( 25608926) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Quantitative traits ( 19197348) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		18 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN TTF1	34 interacting genes: AURKA AXIN2 BCL10 BUB1 CDH1 CTBP1 CTBP2 DCC DLC1 EGFR ENO1 EP300 FBXW7 FLCN GATA1 H2AC6 HMGA1 HSPA1A KAT6A KRAS MCC MED17 MLH3 NRAS ODC1 PTPRJ SMAD4 SP100 SRC THAP11 TLR2 TRAF3 WHRN ZBTB1
Entrez ID		25861	55363
HPRD ID		09718	17100
Ensembl ID		ENSG00000095397	ENSG00000136929
Uniprot IDs		B9EGE6 Q9P202	Q9BXL5
PDB IDs		1UEZ 1UF1 1UFX 6KZ1 7EP7
Enriched GO Terms of Interacting Partners?		Stereocilium Base Stereocilium Mitotic Spindle Organization Auditory Receptor Cell Stereocilium Organization	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Population Proliferation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Transcription Coregulator Binding Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Cell Development Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Cellular Component Organization Regulation Of Developmental Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Developmental Process Positive Regulation Of Intracellular Signal Transduction Hemopoiesis Transcription Coactivator Activity
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