ASF1A and TLK2

Number of citations of the paper that reports this interaction (PubMedID 11470414)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ASF1A	TLK2
Description		anti-silencing function 1A histone chaperone	tousled like kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Histone Chaperone Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Osteoblast Differentiation DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response Replication Fork Processing Muscle Cell Differentiation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Chromatin Organization Protein Phosphorylation DNA Damage Response Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Nucleus Localization Cellular Response To Gamma Radiation Regulation Of Chromatin Organization
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs			Fostamatinib
Diseases
GWAS		Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ASF1B CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4C1 H4C11 H4C12 H4C13 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17	19 interacting genes: ASF1A ASF1B AURKA CEP70 DCAF7 DMAP1 DOCK1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		25842	11011
HPRD ID		16459	10527
Ensembl ID		ENSG00000111875	ENSG00000146872
Uniprot IDs		Q9Y294	A0A804HJZ9 A0A804HK10 B4DUC2 J3QLK5 Q86UE8
PDB IDs		1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H 6ZUF 7LNY 7LO0 7V6Q 8BV1 8CJ1 8CJ2 8CJ3 8Z50	5O0Y 7LO0
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Structural Constituent Of Chromatin Nucleosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Chromatin Organization Telomere Organization Chromatin Remodeling Chromosome, Telomeric Region Protein Localization To Chromatin Protein Heterodimerization Activity Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Protein-containing Complex Assembly Protein-containing Complex Chromosome Organization Protein-containing Complex Organization Chromosome Regulation Of Myeloid Cell Differentiation Cellular Component Assembly Regulation Of Hemopoiesis Extracellular Exosome Protein Localization To Organelle Nucleoplasm Negative Regulation Of Cell Differentiation DNA Binding DNA Replication-dependent Chromatin Assembly Regulation Of Cell Development Negative Regulation Of Developmental Process Intracellular Protein Localization Extracellular Region Organelle Organization RNA Binding Regulation Of Cell Differentiation Nucleus Regulation Of Multicellular Organismal Development Regulation Of Immune System Process CAF-1 Complex Regulation Of Developmental Process Histone Binding Protein Phosphorylation Protein Binding DNA Damage Response Phosphorylation RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Chromatin Organization DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of Vacuole Organization Negative Regulation Of Autophagosome Assembly Histone Chaperone Activity Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Toll-like Receptor Signaling Pathway Chromatin Positive Regulation Of Metalloendopeptidase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding SUMO Conjugating Enzyme Activity Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleus Regulation Of Autophagosome Assembly
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