SVIP and CDR2L

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		SVIP	CDR2L
Description		small VCP interacting protein	cerebellar degeneration related protein 2 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Secretory Granule Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding ATPase Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Autophagy Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Lipidation Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of VCP-NPL4-UFD1 AAA ATPase Complex Assembly Negative Regulation Of ERAD Pathway	Vesicle Transport Along Microtubule Golgi To Secretory Granule Transport
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Dialysis-related mortality ( 21546767)	Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756)
Interacting Genes		3 interacting genes: CDR2L UBXN6 VCP	61 interacting genes: ANKRD11 BFSP2 C1orf216 C4orf46 CCDC146 CCDC185 CCDC187 CCHCR1 COX5B DRC12 EHHADH ELOA FAIM FAM161A FAM161B FAM86C1P HDAC4 HSF2BP INO80B KRT31 KRTAP13-4 LENG1 MESD OIP5 PPP1R18 PRPF31 RASAL3 RASD1 REL RINT1 SCNM1 SH2D4A SPMIP6 SPRY1 STX11 SVIP TBRG4 TCEANC TCHP TCP10L TFIP11 TSGA10IP UBE2I USP7 WASHC1 ZBTB42 ZNF19 ZNF250 ZNF35 ZNF417 ZNF572 ZNF629 ZNF648 ZNF655 ZNF669 ZNF688 ZNF80 ZNF835 ZSCAN22 ZSCAN23 ZSCAN26
Entrez ID		258010	30850
HPRD ID			11041
Ensembl ID		ENSG00000198168	ENSG00000109089
Uniprot IDs		Q8NHG7	Q86X02
PDB IDs
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Endosome To Lysosome Transport ERAD Pathway Flavin Adenine Dinucleotide Catabolic Process Lysosomal Transport VCP-NSFL1C Complex Intracellular Transport Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Macroautophagy Vacuolar Transport Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Golgi To Secretory Granule Transport Response To Endoplasmic Reticulum Stress Cytoplasm Protein Quality Control Endosomal Transport Cellular Localization BAT3 Complex Binding Establishment Of Localization In Cell Positive Regulation Of Protein Deubiquitination Autophagy Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Stress Granule Disassembly Deubiquitinase Activator Activity Protein-DNA Covalent Cross-linking Repair Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential ATPase Complex Cellular Response To Misfolded Protein Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Cellular Response To Arsenic-containing Substance MHC Class I Protein Binding Regulation Of ATP Biosynthetic Process Ubiquitin-specific Protease Binding	Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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