GABRR1 and SQSTM1

Number of citations of the paper that reports this interaction (PubMedID 12431995)
0

Data Source:
HPRD (two hybrid, in vitro)

		GABRR1	SQSTM1
Description		gamma-aminobutyric acid type A receptor subunit rho1	sequestosome 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Presynaptic Membrane Synapse Postsynaptic Membrane Intracellular Vesicle Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Identical Protein Binding Protein-containing Complex Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		GABA receptor activation	NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2
Drugs		Lindane Picrotoxin Fludiazepam TPMPA
Diseases			Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	110 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NSD3 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SLIT3 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ
Entrez ID		2569	8878
HPRD ID		15921	03319
Ensembl ID		ENSG00000146276	ENSG00000161011
Uniprot IDs		P24046	Q13501
PDB IDs		8OP9 8OQ6 8OQ7 8OQ8 8OQA 8RH4 8RH7 8RH8 8RH9 8RHG	1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity System Process Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Kinase Activity Regulation Of Steroid Biosynthetic Process Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Steroid Metabolic Process Protein Phosphorylation ATP Binding Plasma Membrane Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Transport Response To Carbohydrate Positive Regulation Of Cholesterol Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cholesterol Biosynthetic Process Nucleotide Binding Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Postsynapse Protein Catabolic Process Dendrite Development Regulation Of Intracellular Signal Transduction Regulation Of Muscle System Process Sperm Midpiece Regulation Of Cholesterol Metabolic Process Protein Targeting To Vacuole Cell Communication Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Intracellular Transport Regulation Of Platelet Activation Positive Regulation Of Calcium-mediated Signaling Response To Stress Induction Of Synaptic Plasticity By Chemical Substance	Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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