NUTM1 and LRRC8E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUTM1	LRRC8E
Description		NUT midline carcinoma family member 1	leucine rich repeat containing 8 VRAC subunit E
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process		Monoatomic Ion Transport Cell Volume Homeostasis Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways			Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		54 interacting genes: ALOX5 AQP1 ARHGEF6 AXIN1 CATSPERT CCDC116 CCDC185 CCHCR1 CDC20B CDK18 CHCHD3 ENKD1 FAM161A GADD45GIP1 GPANK1 HSPBAP1 IFIT2 KANK2 KANSL1 KPNA2 LHX8 LMO1 LMO2 LMO3 LRRC8E MBD3 METTL17 MORN4 MTCL2 NEBL OSTF1 P4HA3 PLEKHF2 PRKAA2 PRKAB2 PRPF18 PSME4 RCOR3 RIC8A SAMD4A SAMD4B SCNM1 SH2D1B SH2D4A SMARCD1 TBC1D21 TEAD4 TLE5 TP53BP2 TSGA10IP TTC23 TXN2 ZMYND10 ZNF277	7 interacting genes: FBXO7 GPSM2 LNX2 NUTM1 SAMD4B TRIM2 TRIM3
Entrez ID		256646	80131
HPRD ID		10606	08670
Ensembl ID		ENSG00000184507	ENSG00000171017
Uniprot IDs		A0AAG2UVG0 A0AAG2UVR5 A0AAG2UXE6 Q86Y26	Q6NSJ5
PDB IDs		7XEZ 7XFG
Enriched GO Terms of Interacting Partners?		Protein Binding	Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasomal Protein Catabolic Process Neural Precursor Cell Proliferation Lateral Cell Cortex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Lewy Body Core Cell Cortex Region Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly Post-translational Protein Modification Regulation Of Protein Localization To Cell Cortex
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