RALGAPA1 and SRP54

		RALGAPA1	SRP54
Description		Ral GTPase activating protein catalytic subunit alpha 1	signal recognition particle 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	GTPase Activator Activity Protein Heterodimerization Activity	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		RHOH GTPase cycle	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 32888494) Red blood cell count ( 32888494)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		4 interacting genes: ATP6V1A ERBB3 SRP54 TCF3	10 interacting genes: CEBPA EGLN3 KLK12 OGT PRORP RALGAPA1 RNPS1 SRP19 STAB1 TKTL1
Entrez ID		253959	6729
HPRD ID		12324	05330
Ensembl ID		ENSG00000174373	ENSG00000100883
Uniprot IDs		A0A1B0GUI1 A0A7P0TAR5 H0YJB5 Q6GYQ0	G3V480 P61011
PDB IDs			1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ
Enriched GO Terms of Interacting Partners?		Nucleotide Binding ATPase Complex Proton-transporting V-type ATPase, V1 Domain Apical Plasma Membrane Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Endosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Negative Regulation Of Motor Neuron Apoptotic Process Neuregulin Receptor Activity Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway Schwann Cell Differentiation ERBB3 Signaling Pathway Protein Tyrosine Kinase Activator Activity Neuregulin Binding Endocardial Cushion Development Regulation Of Cardiac Muscle Tissue Development Protein Heterodimerization Activity Leukocyte Differentiation Signal Recognition Particle Cotranslational Protein Targeting To Membrane Exocrine Pancreas Development Endoplasmic Reticulum Signal Peptide Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation 7S RNA Binding SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition SRP-dependent Cotranslational Protein Targeting To Membrane Vitamin D Response Element Binding B Cell Lineage Commitment Immunoglobulin V(D)J Recombination Mitogen-activated Protein Kinase Kinase Kinase Binding Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade V(D)J Recombination Positive Regulation Of Striated Muscle Tissue Development ERBB2 Signaling Pathway Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Peripheral Nervous System Development Granulocyte Differentiation
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