GAST and CP

Number of citations of the paper that reports this interaction (PubMedID 463490)
0

Data Source:
HPRD (in vitro)

		GAST	CP
Description		gastrin	ceruloplasmin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Hormone Activity Protein Binding	Ferroxidase Activity Glutathione Peroxidase Activity Copper Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Metal Ion Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein-folding Chaperone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Food	Intracellular Copper Ion Homeostasis Intracellular Iron Ion Homeostasis Cellular Oxidant Detoxification
Pathways		G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport
Drugs		Oxetacaine	Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Subcutaneous adipose tissue ( 22589738)
Interacting Genes		24 interacting genes: AQP6 AQP9 ASPH BCL2L13 CISD2 CP CPE CREB3L1 CYB5R3 ERGIC3 FAM209A GOLM1 GPR152 KIR2DL3 KRT34 LHFPL2 MEP1B MMD MME MUC1 PDZK1IP1 PLP1 SLC10A1 TMEM52B	8 interacting genes: ATP7A BTRC GAST HSP90AA1 LTF MPO PLG PROC
Entrez ID		2520	1356
HPRD ID		00671	00317
Ensembl ID		ENSG00000184502	ENSG00000047457
Uniprot IDs		A0A0E3VY36 P01350	A5PL27 P00450
PDB IDs		5WRJ 7F8V 7F8W 7XOW	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?		Membrane	Phagocytic Vesicle Lumen Removal Of Superoxide Radicals Serine-type Peptidase Activity Immune System Process Serine-type Endopeptidase Activity Extracellular Region Response To Food Biological Process Involved In Interaction With Symbiont Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Superoxide Metabolic Process Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Defense Response To Fungus Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Protein Metabolic Process CTP Binding DATP Binding Response To Fungus Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Hypochlorous Acid Biosynthetic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Tissue Remodeling P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Peptidase Activity Response To Gold Nanoparticle Endopeptidase Activity Protein Phosphorylated Amino Acid Binding Secretory Granule Blood Coagulation Coagulation Cellular Detoxification Hemostasis Response To Nutrient Levels Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding Copper Ion Export Rho GDP-dissociation Inhibitor Binding
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