ALPI and BICD1

Number of citations of the paper that reports this interaction (PubMedID 17139249)
35

Data Source:
HPRD (in vitro)

		ALPI	BICD1
Description		alkaline phosphatase, intestinal	BICD cargo adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane	Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Secretory Vesicle
	Molecular Function	Magnesium Ion Binding Protease Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Protein Kinase Binding Small GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Dephosphorylation	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Virion Assembly Protein Localization To Organelle Stress Granule Assembly Constitutive Secretory Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Centrosome
Pathways		Synthesis of PA Post-translational modification: synthesis of GPI-anchored proteins Digestion	COPI-independent Golgi-to-ER retrograde traffic
Drugs		Terpinen-4-ol
Diseases
GWAS		Hepcidin/ferritin ratio ( 27846281) Refractive error ( 32231278)	Emphysema-related traits ( 20709820) Fourth ventricle volume ( 31530798) Intralaminar thalamic nuclei volume ( 34006833) Left ventricular mass x antihypertensive treatment interaction ( 31407531) Normalized brain volume ( 19010793) Obesity-related traits ( 23251661) Pancreatic cancer ( 20686608) Parkinson's disease ( 32201043)
Interacting Genes		9 interacting genes: AGAP1 BICD1 HSPB1 IRF5 KRTAP10-3 KRTAP10-8 KRTAP10-9 NOD2 NOTCH2NLA	15 interacting genes: ALPI CPNE4 DCTN1 DCTN2 DISC1 DSCAM DYNC1I1 FXR1 GSK3A GSK3B MAPK14 NIN PTPN23 RAB6A STAT3
Entrez ID		248	636
HPRD ID		01376	03730
Ensembl ID		ENSG00000163295	ENSG00000151746
Uniprot IDs		P09923	A8MVZ6 F8VZX7 Q96G01
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptidoglycan Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Response To Peptidoglycan Keratin Filament Protein Kinase Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Muramyl Dipeptide Intermediate Filament Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Interleukin-1 Production Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Detection Of Peptidoglycan Regulation Of Notch Signaling Pathway Ubiquitin Binding Regulation Of Interleukin-1 Beta Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteinase Activated Receptor Binding Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Protein Kinase C Inhibitor Activity Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Involved In Immune Response Minus-end-directed Organelle Transport Along Microtubule Regulation Of Protein Kinase C Signaling Anion Binding Postsynaptic Endosome Constitutive Secretory Pathway Transport Along Microtubule Positive Regulation Of Protein Localization To Centrosome Secretory Vesicle Virion Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Tumor Necrosis Factor Production Anterograde Axonal Protein Transport Innate Immune Response-activating Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intestinal Stem Cell Homeostasis Protein Linear Polyubiquitination Carbohydrate Derivative Binding	Axon Dynein Complex Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Developmental Growth Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Differentiation Glutamatergic Synapse Ciliary Basal Body Nervous System Development Regulation Of Glycogen (starch) Synthase Activity Regulation Of Growth Tau Protein Binding Regulation Of Axonogenesis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Microtubule Spindle Pole Negative Regulation Of Catabolic Process Regulation Of Cell Differentiation Cell Projection Organization Cellular Response To Interleukin-3 Regulation Of Mitochondrial Membrane Permeability Regulation Of Type B Pancreatic Cell Development Centriolar Subdistal Appendage Regulation Of Neuron Projection Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Membrane Permeability Protein Kinase Binding Regulation Of Cell Adhesion Microtubule Anchoring At Centrosome Microtubule-based Process Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Axon Extension Beta-catenin Destruction Complex Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Protein Kinase A Catalytic Subunit Binding Establishment Of Organelle Localization Organelle Organization Camera-type Eye Photoreceptor Cell Differentiation Positive Regulation Of Nervous System Development Positive Regulation Of Catabolic Process Regulation Of Multicellular Organismal Development Establishment Of Vesicle Localization
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