IL27 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 12121660)
0

Data Source:
HPRD (in vitro, in vivo)

		IL27	IL27RA
Description		interleukin 27	interleukin 27 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol Cell Surface	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Interleukin-27 Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Signal Transduction Response To Bacterium Positive Regulation Of Type II Interferon Production Regulation Of T Cell Proliferation Innate Immune Response Regulation Of T-helper 1 Cell Differentiation Regulation Of Defense Response To Virus Regulation Of T Cell Activation Response To Gram-positive Bacterium	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Interleukin-27 signaling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Ankylosing spondylitis ( 23749187) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28892062) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 28166215) Crohn's disease ( 28067908 30500874 32581322 21102463) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 1 diabetes ( 25751624 21829393 19430480)	Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		3 interacting genes: IL27RA S100A6 S100P	12 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6
Entrez ID		246778	9466
HPRD ID		16307	09247
Ensembl ID		ENSG00000197272	ENSG00000104998
Uniprot IDs		Q8NEV9	Q6UWB1
PDB IDs		7U7N 7ZXK 8D85 8XWY	7T5M 7U7N 8D85
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Negative Regulation Of T Cell Extravasation Interleukin-27 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Transition Metal Ion Binding Negative Regulation Of Lymphocyte Migration Negative Regulation Of Interleukin-17 Production Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Migration Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Cellular Extravasation Negative Regulation Of Type 2 Immune Response Calcium Ion Binding Protein Homodimerization Activity Microvillus Membrane Regulation Of Isotype Switching Regulation Of Type 2 Immune Response Regulation Of T-helper 17 Type Immune Response Regulation Of Cellular Extravasation Negative Regulation Of Mononuclear Cell Migration	Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport
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