DEFB121 and NECTIN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEFB121	NECTIN4
Description		defensin beta 121	nectin cell adhesion molecule 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Plasma Membrane Adherens Junction Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Virus Receptor Activity Protein Binding Identical Protein Binding Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell
Pathways		Beta defensins Defensins	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs			Enfortumab vedotin
Diseases			Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Prudent dietary pattern ( 28644415)
Interacting Genes		10 interacting genes: CD40 CLEC2D FAM209A GJA8 IL27RA LAYN LRRC25 NECTIN4 SSMEM1 SYNE4	6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		245934	81607
HPRD ID		16791	17934
Ensembl ID		ENSG00000204548	ENSG00000143217
Uniprot IDs		A0A384MDM0 Q5GRF9 Q5J5C9	K4PZ75 Q96NY8
PDB IDs			4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching Regulation Of Lymphocyte Mediated Immunity Membrane Negative Regulation Of T Cell Extravasation Regulation Of Immunoglobulin Production Interleukin-27 Receptor Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin	Cell-cell Contact Zone Cell Adhesion Molecule Binding Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor Activity Regulation Of Natural Killer Cell Mediated Immunity Immune Response Virus Receptor Activity Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Leukocyte Mediated Cytotoxicity Cell-cell Adhesion Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Sperm Mitochondrion Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Presynaptic Membrane Innate Immune Response Leukocyte Mediated Immunity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Identical Protein Binding Membrane Curvature Sensor Activity Defense Response To Symbiont Cell-cell Junction Organization Defense Response To Other Organism Adherens Junction Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Killing Regulation Of Lymphocyte Mediated Immunity Actin Filament Binding Cell-cell Junction Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Adhesion Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Immune Response Positive Regulation Of Mast Cell Activation Growth Cone Membrane Zonula Adherens
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