VGLL2 and TEAD3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		VGLL2	TEAD3
Description		vestigial like family member 2	TEA domain transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Female Pregnancy Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Asymmetric Neuroblast Division
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body size at age 10 ( 32376654) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Height ( 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 28604730) Night sleep phenotypes ( 27126917) Serum total protein levels ( 29403010) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Offspring birth weight ( 31043758)
Interacting Genes		3 interacting genes: MEF2C TEAD1 TEAD3	14 interacting genes: AP4S1 CTBP2 E2F1 E2F3 KIFC2 MYH7 PHB2 PIDD1 SUMO2 VGLL1 VGLL2 VGLL3 WWTR1 YAP1
Entrez ID		245806	7005
HPRD ID		18282	04411
Ensembl ID		ENSG00000170162	ENSG00000007866
Uniprot IDs		Q8N8G2	A0A7P0SNI2 Q99594
PDB IDs			5EMW 7CNL 7ZJQ 8P0M
Enriched GO Terms of Interacting Partners?		Hippo Signaling Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification DNA-binding Transcription Factor Activity Animal Organ Development Muscle Cell Fate Determination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Glomerulus Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Sinoatrial Valve Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Organ Development TEAD-YAP Complex Asymmetric Neuroblast Division Transcription Regulator Complex Positive Regulation Of Growth Regulation Of Synaptic Activity Positive Regulation Of RNA Biosynthetic Process Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of DNA-templated Transcription AMPA Selective Glutamate Receptor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Fear Response Cellular Response To Parathyroid Hormone Stimulus DNA Binding Cardiac Ventricle Formation Positive Regulation Of Behavioral Fear Response Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Skeletal Muscle Cell Differentiation Cellular Response To Antibiotic Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Chamber Formation Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Myeloid Cell Apoptotic Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Behavioral Fear Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Secondary Heart Field Specification Negative Regulation Of Vascular Endothelial Cell Proliferation Heart Field Specification Neural Crest Cell Differentiation Asymmetric Cell Division	Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fat Cell Differentiation DNA-binding Transcription Activator Activity Positive Regulation Of Macromolecule Metabolic Process Hippo Signaling Heart Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Gene Expression Enterocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of The Force Of Skeletal Muscle Contraction Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Osteoblast Differentiation Mitochondrial Prohibitin Complex Nucleus Cis-regulatory Region Sequence-specific DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation TEAD-YAP Complex Regulation Of Cytochrome-c Oxidase Activity Amide Binding Endopeptidase Complex Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Signal Transduction By P53 Class Mediator Lens Fiber Cell Apoptotic Process Lateral Mesoderm Development
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