FJX1 and DKKL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FJX1	DKKL1
Description		four-jointed box kinase 1	dickkopf like acrosomal protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Acrosomal Vesicle Extracellular Region Extracellular Space Cytoplasmic Vesicle
	Molecular Function		Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Cell-cell Signaling Retina Layer Formation	Penetration Of Zona Pellucida Anatomical Structure Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Testosterone Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Femoral neck bone mineral density ( 30172743)	Multiple sclerosis ( 21833088 24076602)
Interacting Genes		3 interacting genes: DKKL1 PIGN WT1	2 interacting genes: C11orf71 FJX1
Entrez ID		24147	27120
HPRD ID		16897	10396
Ensembl ID		ENSG00000179431	ENSG00000104901
Uniprot IDs		Q86VR8	A0A140VK15 Q9UK85
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Mannose-ethanolamine Phosphotransferase Activity Negative Regulation Of Testosterone Biosynthetic Process Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Regulation Of Testosterone Biosynthetic Process Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Penetration Of Zona Pellucida Receptor Antagonist Activity Co-receptor Binding Metanephric Epithelium Development Muscle Cell Fate Commitment Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Glomerulus Development C2H2 Zinc Finger Domain Binding Male Genitalia Development Mesenchymal To Epithelial Transition Positive Regulation Of Apoptotic Process Renal Tubule Morphogenesis Positive Regulation Of Programmed Cell Death Skeletal Muscle Organ Development Cellular Response To Gonadotropin Stimulus Circulatory System Development Regulation Of Ketone Biosynthetic Process Sex Determination Reproductive System Development Adrenal Gland Development Negative Regulation Of Steroid Biosynthetic Process Response To Gonadotropin GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Negative Regulation Of Steroid Metabolic Process	Retina Layer Formation
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