APOL2 and MARCHF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOL2	MARCHF3
Description		apolipoprotein L2	membrane associated ring-CH-type finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Membrane Membrane	Lysosome Endosome Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Acute-phase Response Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy	Endocytosis Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Epigenetic age acceleration in alcohol use disorder ( 31466081)
Interacting Genes		38 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 ELOVL4 EMP1 ERGIC3 FAM209A FAM210B GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 SLC35H1 STX1A STX2 TIMMDC1 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6	10 interacting genes: APOL2 APP FATE1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2K UBE2W
Entrez ID		23780	115123
HPRD ID		06263	14362
Ensembl ID		ENSG00000128335	ENSG00000173926
Uniprot IDs		Q9BQE5	Q86UD3
PDB IDs		7LF8
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K11-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process ISG15 Transferase Activity ATP Binding ISG15-protein Conjugation Protein Modification Process Macromolecule Catabolic Process Nucleotide Binding Transferase Activity Proteolysis Macromolecule Metabolic Process Protein K6-linked Ubiquitination Lipoprotein Metabolic Process Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Ubiquitin Protein Ligase Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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