KCNE4 and KCNA1

Number of citations of the paper that reports this interaction (PubMedID 12944270)
67

Data Source:
HPRD (in vitro)

		KCNE4	KCNA1
Description		potassium voltage-gated channel subfamily E regulatory subunit 4	potassium voltage-gated channel subfamily A member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Voltage gated Potassium channels
Drugs		Enflurane Promethazine Miconazole	Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases			Episodic ataxias
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Appendicular lean mass ( 33097823) Body mass index ( 20966902) Coronary artery disease in type 1 diabetes ( 32077919) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Recurrent major depressive disorder x sex interaction ( 34099189) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX	19 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 LAG3 MAL NOMO1 SGTA TMEM14B TMEM86A
Entrez ID		23704	3736
HPRD ID		09689	08885
Ensembl ID		ENSG00000152049	ENSG00000111262
Uniprot IDs		Q8WWG9	Q09470
PDB IDs
Enriched GO Terms of Interacting Partners?		GET Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Metal Ion Transport Regulation Of Muscle System Process Endoplasmic Reticulum Tail-anchored Membrane Protein Insertion Into ER Membrane Transmembrane Transporter Binding Regulation Of Membrane Potential Monoatomic Cation Transport Monoatomic Ion Transport Membrane Repolarization During Action Potential Delayed Rectifier Potassium Channel Activity Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Muscle Contraction Membrane Repolarization Detection Of Mechanical Stimulus Involved In Sensory Perception Protein Insertion Into ER Membrane Regulation Of Biological Quality Positive Regulation Of Potassium Ion Transport Response To Mechanical Stimulus Regulation Of Membrane Repolarization Regulation Of System Process Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Detection Of Mechanical Stimulus Renal Absorption Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Regulation Of Monoatomic Cation Transmembrane Transport Homeostatic Process Regulation Of Platelet Activation Voltage-gated Potassium Channel Activity Inorganic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Perinuclear Region Of Cytoplasm Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Gastrin-induced Gastric Acid Secretion Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Protein Insertion Into Membrane Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Transport Neuronal Cell Body Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transport	Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization
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