PRKD3 and MYH3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		PRKD3	MYH3
Description		protein kinase D3	myosin heavy chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ciliary Basal Body	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament Contractile Muscle Fiber Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Myosin Phosphatase Activity Actin Filament Binding
	Biological Process	Protein Phosphorylation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Intracellular Signal Transduction	Skeletal Muscle Contraction Muscle Contraction Muscle Organ Development Actin Filament-based Movement Muscle Filament Sliding Embryonic Limb Morphogenesis Sarcomere Organization ATP Metabolic Process Face Morphogenesis
Pathways		Sphingolipid de novo biosynthesis	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA)
GWAS		Alzheimer's disease ( 34099642) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 24292274 28165464) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 23974872 33169155) Systolic blood pressure ( 27841878 28135244)	Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Relative hand skill in reading disability ( 24068947)
Interacting Genes		13 interacting genes: BCL6 DLAT DYNLL2 GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2	11 interacting genes: APPL1 CLIP4 DYSF GNG5 LAIR1 LAMTOR5 OPTN PPP1R7 PRKD3 SNAPIN TULP3
Entrez ID		23683	4621
HPRD ID		06151	01172
Ensembl ID		ENSG00000115825	ENSG00000109063
Uniprot IDs		O94806	P11055 Q5GJ67
PDB IDs		2D9Z
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Negative Regulation Of Mitotic Cell Cycle DNA Replication Somatic Diversification Of Immunoglobulins Positive Regulation Of Proteolysis Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Spindle Localization Mitotic Metaphase Chromosome Alignment Positive Regulation Of Androgen Receptor Signaling Pathway Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Myosin V Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Metaphase Chromosome Alignment Chromosome Localization Establishment Of Organelle Localization Spindle Localization Spindle Assembly Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of Protein Autoubiquitination Linear Polyubiquitin Binding 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity	Negative Regulation Of Phagocytosis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?