KPNA6 and CSE1L

Number of citations of the paper that reports this interaction (PubMedID 10523667)
46

Data Source:
HPRD (in vitro)

		KPNA6	CSE1L
Description		karyopherin subunit alpha 6	chromosome segregation 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Protein Transport
Pathways		Assembly of the ORC complex at the origin of replication
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Anger ( 24489884) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Non-response to citalopram or escitalopram and depression ( 27622933) Response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Subjective well-being ( 27089181)
Interacting Genes		35 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS DYRK1A EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 OGT POLR3C POM121 POU6F2 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	20 interacting genes: BIRC2 CDC42 CDH1 DUX4 HNRNPL KPNA1 KPNA4 KPNA6 KPNB1 MAPK6 MTNR1B PPP5C RAN RNF10 RPL22 STAT1 SUMO2 TMEM62 YWHAG YWHAQ
Entrez ID		23633	1434
HPRD ID		09465	03217
Ensembl ID		ENSG00000025800	ENSG00000124207
Uniprot IDs		O60684	A0A384NKW7 P55060
PDB IDs		4UAD 7RHT
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Stress P53 Binding Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Cytokine Production Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Erythrocyte Differentiation Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Transcription Coactivator Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Erythrocyte Differentiation Regulation Of Programmed Cell Death Transcription Coactivator Binding	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Import Into Nucleus Protein-containing Complex Protein Localization To Nucleus Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport RNA Import Into Nucleus Postsynapse To Nucleus Signaling Pathway Glutamatergic Synapse Establishment Of Protein Localization To Organelle Importin-alpha Family Protein Binding Cytoplasm Protein Localization To Organelle Intracellular Protein Localization Nucleus Protein Domain Specific Binding Response To Hydrogen Peroxide Positive Regulation Of Hippo Signaling Intracellular Protein Transport Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization Ubiquitin-like Protein Ligase Binding Cytosol Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Response To Reactive Oxygen Species Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Localization Substantia Nigra Development Focal Adhesion Positive Regulation Of Protein Import Into Nucleus RNA Binding Regulation Of Hippo Signaling Hsp90 Protein Binding Translation At Presynapse Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Extracellular Exosome
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