MKRN2 and MRPS25

		MKRN2	MRPS25
Description		makorin ring finger protein 2	mitochondrial ribosomal protein S25
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Structural Constituent Of Ribosome
	Biological Process	Protein Polyubiquitination Negative Regulation Of Inflammatory Response To Antigenic Stimulus DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Mitochondrial Translation
Pathways			Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		Hip index ( 34021172) Monocyte percentage of white cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		16 interacting genes: AIRIM CLK1 EIF3F IGF2BP3 MRPS25 NDN PALS2 PDLIM2 RACK1 RBCK1 RELA UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3	9 interacting genes: CAND2 COLQ ERCC6 FBLN2 HDAC11 MKRN2 NUAK1 UBC XPC
Entrez ID		23609	64432
HPRD ID		09761	17594
Ensembl ID		ENSG00000075975	ENSG00000131368
Uniprot IDs		Q9H000	P82663
PDB IDs			3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein Metabolic Process Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Translation Regulator Activity Ubiquitin Protein Ligase Binding Regulation Of Protein Modification Process Translation Positive Regulation Of Protein Modification Process Protein Modification Process Transferase Activity Positive Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process NF-kappaB P50/p65 Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Protein Catabolic Process Nucleus Cytosol Positive Regulation Of NF-kappaB Transcription Factor Activity	Pyrimidine Dimer Repair Response To UV-B Site Of DNA Damage Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleotide-excision Repair Heteroduplex DNA Loop Binding Nucleotide-excision Repair Factor 2 Complex Post-translational Protein Modification Protein Modification Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein DNA Damage Checkpoint Signaling Acetylcholine Catabolic Process In Synaptic Cleft SCF Complex Assembly Extracellular Matrix Structural Constituent XPC Complex Acetylcholine Catabolic Process DNA Damage Sensor Activity Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To UV Signal Transduction In Response To DNA Damage Response To Superoxide Nucleotide-excision Repair Complex DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Bubble DNA Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Extracellular Matrix Constituent Conferring Elasticity Regulation Of Synaptic Assembly At Neuromuscular Junction Histone Deacetylase Activity, Hydrolytic Mechanism Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair UV-damage Excision Repair Negative Regulation Of Cell Cycle Phase Transition
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