MKRN1 and KCNH1

Number of citations of the paper that reports this interaction (PubMedID 33647316)
51

Data Source:
BioGRID (pull down)

		MKRN1	KCNH1
Description		makorin ring finger protein 1	potassium voltage-gated channel subfamily H member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nuclear Inner Membrane Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Early Endosome Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Lipid Binding Cyclic Nucleotide Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination	Monoatomic Ion Transport Potassium Ion Transport Myoblast Fusion Monoatomic Ion Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Membrane Potential Transmembrane Transport Cellular Response To Calcium Ion Potassium Ion Transmembrane Transport
Pathways		AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Voltage gated Potassium channels
Drugs			Enflurane Imipramine Astemizole Promethazine Miconazole
Diseases
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Immature fraction of reticulocytes ( 32888494) Number of sexual partners ( 30643258)	Blond vs. brown/black hair color ( 30531825) Bone mineral density (femoral neck) ( 27424934) Bone mineral density (spine) and age at menarche ( 26312577) Bone mineral density (total hip) ( 27424934) Cancer ( 27197191) Cholesterol ( 31902109) Circulating vasoactive peptide levels ( 23381795) Cobalt levels ( 26025379) Hematocrit ( 32888494) Hemoglobin ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		28 interacting genes: APC ASH2L BYSL CDKN2A CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A KCNH1 MAP1LC3B MTURN NAA10 OTUB2 PABPC1 RAD23A RAD23B RPS10 SDCBP SLC13A1 TSC2 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1	11 interacting genes: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 MKRN1 MTDH NTAQ1 SDCBP
Entrez ID		23608	3756
HPRD ID		09673	04492
Ensembl ID		ENSG00000133606	ENSG00000143473
Uniprot IDs		Q9UHC7	O95259
PDB IDs			5J7E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cytosol Nucleus Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Cytoplasm Proteolysis Protein Polyubiquitination Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Ubiquitin Protein Ligase Binding Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein K11-linked Deubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Post-translational Protein Modification TOR Signaling Proteasome Binding Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Ubiquitin Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Protein K6-linked Ubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Positive Regulation Of Viral Genome Replication Macromolecule Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Damage Response Ligase Inhibitor Activity Cyclic Nucleotide Binding Interleukin-5 Receptor Complex Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Polyubiquitin Modification-dependent Protein Binding	Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Transmembrane Transporter Binding Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Action Potential Calyx Of Held Neuronal Cell Body Membrane Dendrite Membrane Protein Homooligomerization Potassium Channel Regulator Activity Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Complex Oligomerization Regulation Of Action Potential Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Inorganic Ion Transmembrane Transport Neural Nucleus Development Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Metal Ion Transport Response To Metal Ion Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Regulation Of Potassium Ion Transport Interleukin-5 Receptor Binding Protein-N-terminal Asparagine Amidohydrolase Activity Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Docking Regulation Of Transport Positive Regulation Of Norepinephrine Secretion Monoatomic Ion Transport Globus Pallidus Development Gated Channel Activity Neuron Projection Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Biological Quality
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