RIGI and CYLD

Number of citations of the paper that reports this interaction (PubMedID 18636086)
25

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RIGI	CYLD
Description		RNA sensor RIG-I	CYLD lysine 63 deubiquitinase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Cell Projection Organelle Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Protein Kinase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Met1-linked Polyubiquitin Deubiquitinase Activity Proline-rich Region Binding K48-linked Deubiquitinase Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response	Immune System Process Proteolysis Canonical NF-kappaB Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Negative Regulation Of JNK Cascade Homeostasis Of Number Of Cells Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Necroptotic Process Necroptotic Process Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Protein Localization Protein Linear Deubiquitination Negative Regulation Of Interleukin-18-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases			Brooke-Spiegler syndrome Multiple familial trichoepithelioma Familial cylindromatosis
GWAS			Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 22412388 28067908) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 22019778 25642632) Lumbar spine bone mineral density ( 22504420 29499414) Serum metabolite levels ( 33031748)
Interacting Genes		23 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PKD1 PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3 VPS26C	29 interacting genes: AKT1 CENPV DLG4 DYRK1A GRIA1 GRIA2 HDAC6 IKBKE IKBKG ITCH KLHL21 MAP3K7 MAPK3 MAPRE1 MIB2 MLKL PLK4 PTPA RIGI RNF166 TBK1 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S
Entrez ID		23586	1540
HPRD ID		13131	05427
Ensembl ID		ENSG00000107201	ENSG00000083799
Uniprot IDs		A0AAQ5BIG4 O95786	Q9NQC7
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0	1IXD 1WHL 1WHM 2VHF 7OWC 7OWD
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding	Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of Type I Interferon Production Identical Protein Binding Protein K29-linked Ubiquitination Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Cytosol Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Cytoplasm Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process Activation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Positive Regulation Of Macroautophagy Toll-like Receptor 4 Signaling Pathway Regulation Of Macroautophagy Anoikis Positive Regulation Of Immune Response Macromolecule Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Programmed Cell Death Immune Response-activating Signaling Pathway Cell Death Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cell Communication
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