FPR2 and APOD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FPR2	APOD
Description		formyl peptide receptor 2	apolipoprotein D
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity RAGE Receptor Binding	Lipid Transporter Activity Protein Binding Lipid Binding Cholesterol Binding
	Biological Process	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Communication Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Dentinogenesis Cellular Response To Amyloid-beta	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Response To Stress Brain Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Vitamin A Copper
Diseases
GWAS		Alopecia areata ( 25608926) Multiple sclerosis ( 24076602 31604244) Tourette syndrome ( 30818990)	HDL cholesterol levels ( 32203549)
Interacting Genes		6 interacting genes: APOD CAMP ERC1 FXYD6 LRRC25 SSMEM1	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35H1 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		2358	347
HPRD ID		00647	00134
Ensembl ID		ENSG00000171049	ENSG00000189058
Uniprot IDs		P25090	P05090
PDB IDs		6LW5 6OMM 7T6S 7T6U 7T6V 7WVV 7WVW 7WVX 7WVY 8Y62 8Y63	2HZQ 2HZR
Enriched GO Terms of Interacting Partners?		Regulation Of Chemokine Production Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Butyrate Prostaglandin Production Involved In Inflammatory Response Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Butyrate I-kappaB Phosphorylation Presynaptic Membrane Regulation Of Smooth Muscle Cell-matrix Adhesion Arachidonate Metabolite Production Involved In Inflammatory Response Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Cellular Response To Peptidoglycan Dentinogenesis Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Antimicrobial Humoral Response Structural Constituent Of Presynaptic Active Zone IkappaB Kinase Complex Ion Channel Regulator Activity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Sodium Ion Export Across Plasma Membrane Chronic Inflammatory Response Presynaptic Active Zone Organization Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Regulation Of Antimicrobial Humoral Response Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Specific Granule Positive Regulation Of Monocyte Chemotactic Protein-1 Production Production Of Molecular Mediator Involved In Inflammatory Response Cytolysis Response To Peptidoglycan Presynaptic Active Zone Cytoplasmic Component Negative Regulation Of Lymphocyte Migration Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Response To Yeast	Membrane Protein Binding
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