PADI4 and OTUD3

		PADI4	OTUD3
Description		peptidyl arginine deiminase 4	OTU deubiquitinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Chromatin Organization Nucleosome Assembly Chromatin Remodeling Stem Cell Population Maintenance Protein Modification Process Post-translational Protein Modification Innate Immune Response	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination
Pathways		Chromatin modifying enzymes	Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs		Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide Chlortetracycline
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756 32912934) Rheumatoid arthritis ( 21452313 21505073 23143596 24390342 30423114 30572963 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)
Interacting Genes		15 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 MDM2 NPM1 OTUD3 PADI2 POU6F2 RYBP SMURF1 SZRD1 TRIB3	19 interacting genes: ATG14 BGLT3 BHLHE22 CGAS EMC1 FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PADI4 PPARD SIX3 STUB1 TP53 UBC UBE2L3
Entrez ID		23569	23252
HPRD ID		05635	19417
Ensembl ID		ENSG00000159339	ENSG00000169914
Uniprot IDs		Q9UM07	Q5T2D3
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B 8GOD 8R8U 8R8V 8SMK 8SML	4BOU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus Response To Catecholamine Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process NF-kappaB Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Dopamine Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Manganese Ion Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Golgi-associated Vesicle Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Programmed Cell Death	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan
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