TSPAN12 and RNF152

Number of citations of the paper that reports this interaction (PubMedID 33602225)
28

Data Source:
BioGRID (enzymatic study)

		TSPAN12	RNF152
Description		tetraspanin 12	ring finger protein 152
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Lysosome Lysosomal Membrane Membrane Organelle Membrane
	Molecular Function	Protein Binding Wnt Receptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Maintenance Of Blood-brain Barrier Regulation Of Angiogenesis Norrin Signaling Pathway	Protein Polyubiquitination Cytoplasmic Translation Protein Monoubiquitination Apoptotic Process Cellular Response To Starvation Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)	Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate (creatinine) ( 26831199 28452372)
Interacting Genes		21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218	13 interacting genes: CROCC EBP GJA8 KIR2DL3 MYD88 RHEB SERPINB7 TRAF6 TSPAN12 UBE2E1 UBE2N UBE2W UBE3A
Entrez ID		23554	220441
HPRD ID		15509	11514
Ensembl ID		ENSG00000106025	ENSG00000176641
Uniprot IDs		O95859	Q8N8N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Endoplasmic Reticulum Membrane Endoplasmic Reticulum	Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of TOR Signaling Response To Virus Protein Monoubiquitination Interleukin-33-mediated Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity TOR Signaling Cellular Response To Nutrient Levels Antiviral Innate Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Negative Regulation Of TOR Signaling Defense Response To Virus MyD88-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of DNA-binding Transcription Factor Activity Tissue Homeostasis Anatomical Structure Homeostasis Lipopolysaccharide-mediated Signaling Pathway Response To Nutrient Levels Regulation Of Protein Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Induced Systemic Resistance Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Sperm Entry Positive Regulation Of Golgi Lumen Acidification
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