QPRT and GIT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		QPRT	GIT2
Description		quinolinate phosphoribosyltransferase	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Catalytic Complex	Nucleoplasm Focal Adhesion Synapse Presynapse
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Identical Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process Quinolinate Catabolic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Quinolinate Metabolic Process	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling
Pathways		Nicotinate metabolism	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs		Niacin
Diseases
GWAS			Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		11 interacting genes: ADAMTSL4 BCKDK ETS1 GIT2 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-8 KRTAP4-12 NOTCH2NLA SUFU	47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		23475	9815
HPRD ID		06950	09779
Ensembl ID		ENSG00000103485	ENSG00000139436
Uniprot IDs		B4DDH4 H3BP73 Q15274 V9HWJ5	F8VXI9 F8W822 Q14161 Q6FI58
PDB IDs		2JBM 4KWV 4KWW 5AYX 5AYY 5AYZ
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Pigment Cell Development	Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation
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