ETHE1 and IGSF21

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ETHE1	IGSF21
Description		ETHE1 persulfide dioxygenase	immunoglobin superfamily member 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Plasma Membrane External Side Of Plasma Membrane Membrane Cell Junction Presynaptic Membrane Synapse Postsynaptic Membrane Inhibitory Synapse Side Of Membrane Postsynaptic Density Membrane
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Sulfur Dioxygenase Activity Dioxygenase Activity
	Biological Process	Glutathione Metabolic Process Hydrogen Sulfide Metabolic Process	Synapse Maturation Trans-synaptic Signaling, Modulating Synaptic Transmission
Pathways		Sulfide oxidation to sulfate
Drugs
Diseases
GWAS			Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		9 interacting genes: APP ATG9A ATP6V1H GORASP2 IGSF21 KRTAP19-2 LRIF1 RELA TXN2	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		23474	84966
HPRD ID		09764	11309
Ensembl ID		ENSG00000105755	ENSG00000117154
Uniprot IDs		A0A0S2Z580 A0A0S2Z5B3 A0A0S2Z5N8 B2RCZ7 O95571	Q96ID5
PDB IDs		4CHL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Positive Regulation Of Amyloid Precursor Protein Catabolic Process Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Positive Regulation Of Interleukin-1 Production Response To Interleukin-1 Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Interleukin-6 Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Interleukin-1 Beta Production NF-kappaB P50/p65 Complex Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Purine-containing Compound Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation
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