CAPN7 and IST1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CAPN7	IST1
Description		calpain 7	IST1 factor associated with ESCRT-III
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Extracellular Exosome	Chromatin Extracellular Region Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Cytoskeleton Midbody Cytoplasmic Vesicle Azurophil Granule Lumen Extracellular Exosome Flemming Body
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding
	Biological Process	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis	Intracellular Protein Localization Protein Transport Multivesicular Body Assembly Establishment Of Protein Localization Positive Regulation Of Proteolysis Collateral Sprouting Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis Midbody Abscission ESCRT III Complex Disassembly
Pathways		Degradation of the extracellular matrix	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655	12 interacting genes: APEH ATXN1 BAG4 CALB2 CAPN7 DSCAM OGT SPAST TOX3 UBQLN1 UBQLN2 WWP2
Entrez ID		23473	9798
HPRD ID		05908	13784
Ensembl ID		ENSG00000131375	ENSG00000182149
Uniprot IDs		Q7Z479 Q9Y6W3	B4DXC9 P53990
PDB IDs		2QFE 8UC6	3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA 7S7J 8UC6 8V2Q 8V2R 8V2S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Proteolysis Cytosol Positive Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Regulation Of ERAD Pathway Social Behavior Positive Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Modification Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Nucleus Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Autophagy Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Omega Peptidase Activity Mitotic Spindle Disassembly Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein O-acetylglucosaminyltransferase Activity MIT Domain Binding Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Monoatomic Ion Transport Autophagosome Organization POZ Domain Binding Negative Regulation Of Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Cellular Component Assembly Positive Regulation Of Microtubule Depolymerization Microtubule Severing ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
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