CBX5 and TAF4

Number of citations of the paper that reports this interaction (PubMedID 11959914)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		CBX5	TAF4
Description		chromobox 5	TATA-box binding protein associated factor 4
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex MLL1 Complex
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity	Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Ovarian Follicle Development Regulation Of DNA Repair DNA-templated Transcription DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 28892062) Fasting glucose ( 33381925) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		62 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FES FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	22 interacting genes: AHR ATF7 CBX3 CBX5 CREM GTF2A1 GTF2A2 H3-4 HTT JUN SP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF5 TAF6 TAF7 TAF8 TAF9 TCF12
Entrez ID		23468	6874
HPRD ID		05131	11797
Ensembl ID		ENSG00000094916	ENSG00000130699
Uniprot IDs		P45973 V9HWG0	O00268
PDB IDs		3FDT 3I3C 8UXQ	1H3O 2P6V 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity	Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Initiation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation MRNA Transcription By RNA Polymerase II Protein-DNA Complex Assembly MRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor TFTC Complex Transcription By RNA Polymerase II Protein Heterodimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process TBP-class Protein Binding Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Protein-containing Complex Assembly Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Protein-containing Complex Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA Repair Regulation Of Macromolecule Metabolic Process SAGA Complex RNA Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding MLL1 Complex
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