Wiki-MPM
About
Browse
People
Funding
Updates
SF3B1 and IL7R
Number of citations of the paper that reports this interaction (PubMedID
23151878
)
60
Data Source:
BioGRID
(unspecified method)
SF3B1
IL7R
Description
splicing factor 3b subunit 1
interleukin 7 receptor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Spliceosomal Complex
U2-type Spliceosomal Complex
U2 SnRNP
U12-type Spliceosomal Complex
Nucleolus
Nuclear Speck
Nuclear Lumen
U11/U12 SnRNP
U2-type Prespliceosome
U2-type Precatalytic Spliceosome
Catalytic Step 2 Spliceosome
B-WICH Complex
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
RNA Binding
MRNA Binding
Protein Binding
Splicing Factor Binding
Antigen Binding
Cytokine Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Biological Process
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Chromatin Remodeling
MRNA Processing
RNA Splicing
Positive Regulation Of Transcription By RNA Polymerase I
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
U2-type Prespliceosome Assembly
Regulation Of DNA Recombination
Cell Morphogenesis
B Cell Homeostasis
T Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Size
Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Hemopoiesis
T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-7-mediated Signaling Pathway
B Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Lymph Node Development
Defense Response To Gram-positive Bacterium
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways
B-WICH complex positively regulates rRNA expression
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Interleukin-7 signaling
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
H3B-8800
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Major depressive disorder (
27479909
)
Morning person (
30696823
)
Schizophrenia (
25056061
29483656
30285260
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Waist circumference adjusted for body mass index (
34021172
)
Allergic disease (asthma, hay fever or eczema) (
29785011
29083406
)
Allergic rhinitis (
31361310
30013184
)
Ankylosing spondylitis (
23749187
)
Asthma (
34103634
32296059
31619474
31361310
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Eczema (
31361310
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
21244703
19525953
21833088
24076602
)
Neutrophil percentage of white cells (
27863252
32888494
)
Primary biliary cholangitis (
26394269
21399635
30643196
23000144
28062665
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
25751624
17554260
)
Ulcerative colitis (
21297633
)
White blood cell count (
32888494
)
Interacting Genes
106 interacting genes:
APBB1
C11orf58
CALM1
CLK1
CSNK2A1
DUX4
DYRK1A
ERG
GTF3C3
H3C1
HSPD1
IL7R
MECOM
MELK
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYC
NOP58
NRIP1
NUDT21
PPP1R8
RBM17
RSPH1
SF1
SF3B3
SF3B6
SMAD1
SMAD5
SMAD9
SNIP1
STRADB
SUMO2
TCERG1
TOP1
USP7
WBP4
110 interacting genes:
AGTRAP
ALYREF
APOL3
CIRBP
CPSF1
CRLF2
DDX21
DDX39B
DDX3X
DDX5
DHX36
DHX9
EIF2AK2
ELAVL1
EMG1
FAU
FUS
FYN
G3BP1
H1-10
H1-2
H1-4
H2BC21
HNRNPA0
HNRNPA3
HNRNPAB
HNRNPC
HNRNPD
HNRNPDL
HNRNPH3
HNRNPL
HNRNPR
HNRNPU
HNRNPUL1
HNRNPUL2
IL2RG
IL7
ILF2
ILF3
JAK1
JAK3
KIT
LYN
MALL
MAP4
MS4A1
NCL
NONO
PABPC1
PABPC4
PABPN1
PIK3R1
PTBP1
PTK2B
PTMA
PURA
PURB
QKI
RACK1
RAD21
RBM3
RBMX
RPL15
RPL18
RPL22
RPL29
RPL30
RPL31
RPL6
RPL7
RPL8
RPS20
RPS3
RPSA
RRAGA
RSL1D1
SAFB
SDC4
SF1
SF3A1
SF3B1
SNRNP70
SNRPA
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SRP14
SRP9
SRSF3
SRSF9
SSB
STAT3
STAT5A
STAT5B
SYNCRIP
TMEM120B
TOE1
TOP1
TSLP
U2AF1
U2AF2
YBX1
YBX3
YWHAE
YWHAG
ZNF787
Entrez ID
23451
3575
HPRD ID
09281
00893
Ensembl ID
ENSG00000115524
ENSG00000168685
Uniprot IDs
B4DGZ4
O75533
P16871
PDB IDs
2F9D
2F9J
2FHO
2PEH
3LQV
4OZ1
5IFE
5O9Z
5Z56
5Z57
5Z58
5ZYA
6AH0
6AHD
6EN4
6FF4
6FF7
6N3E
6QX9
6Y50
6Y53
6Y5Q
7ABG
7ABH
7ABI
7B0I
7B91
7B92
7B9C
7DVQ
7EVN
7EVO
7OMF
7ONB
7OPI
7Q3L
7Q4O
7Q4P
7QTT
7SN6
7VPX
8CH6
8H6E
8H6J
8H6K
8H6L
8HK1
8I0P
8I0R
8I0S
8I0T
8I0U
8I0V
8QO9
8QXD
8QZS
8R08
8R09
8R0A
8R0B
8RM5
8Y7E
3DI2
3DI3
3UP1
5J11
6P50
6P67
7OPB
Enriched GO Terms of Interacting Partners
?
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Extracellular Vesicle
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Translation
Regulation Of Macromolecule Metabolic Process
MRNA Destabilization
Regulation Of Metabolic Process
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Vasculature Development
Regulation Of Angiogenesis
Negative Regulation Of Cell Migration
Regulation Of Vasculature Development
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Cytokine Production
Negative Regulation Of Cell Motility
Negative Regulation Of Locomotion
Regulation Of Translation
Regulation Of MRNA Stability
Negative Regulation Of Signal Transduction
Negative Regulation Of Protein Metabolic Process
Regulation Of RNA Stability
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Developmental Process
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Endothelial Cell Migration
RNA Binding
Ribonucleoprotein Complex
Nucleic Acid Binding
RNA Processing
MRNA Processing
RNA Splicing
Spliceosomal Complex
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
MRNA Binding
Nucleus
Catalytic Step 2 Spliceosome
Nucleic Acid Metabolic Process
Regulation Of MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of MRNA Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of RNA Catabolic Process
Positive Regulation Of Gene Expression
Cytoplasmic Translation
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Spliceosomal Complex Assembly
Regulation Of Translation
MRNA Stabilization
Regulation Of MRNA Processing
U4 SnRNP
U1 SnRNP
7-methylguanosine Cap Hypermethylation
U12-type Spliceosomal Complex
U2-type Prespliceosome Assembly
Cytosolic Ribosome
Regulation Of RNA Splicing
Negative Regulation Of Translation
U2 SnRNP
Positive Regulation Of Translation
Ribosome
Positive Regulation Of Cytoplasmic Translation
Regulation Of MRNA Stability
U2-type Spliceosomal Complex
Protein-RNA Complex Assembly
Methylosome
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of RNA Stability
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?