SLC44A1 and KCNE3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SLC44A1	KCNE3
Description		solute carrier family 44 member 1	potassium voltage-gated channel subfamily E regulatory subunit 3
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Vesicle Neuronal Cell Body Membrane Cell Projection Perikaryon Membrane Raft Basolateral Part Of Cell
	Molecular Function	Choline Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Ethanolamine Transmembrane Transporter Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Phosphatidylcholine Biosynthetic Process Choline Transport Ethanolamine Transport Choline Catabolic Process Transmembrane Transport Transport Across Blood-brain Barrier	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Chloride Ion Homeostasis Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Synthesis of PC Choline catabolism SLC-mediated bile acid transport	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases			Brugada syndrome (BRS)
GWAS		Aluminium levels ( 26025379) Behavioral disturbance or psychiatric symptoms in prion disease ( 25897833) Intraocular pressure ( 29617998 30591961) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 19448620) Response to fenofibrate (total cholesterol levels) ( 27002377)	Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)
Interacting Genes		3 interacting genes: C11orf58 KCNE3 NUDT21	10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1
Entrez ID		23446	10008
HPRD ID		16197	07256
Ensembl ID		ENSG00000070214	ENSG00000175538
Uniprot IDs		Q8WWI5	Q6IAE6 Q9Y6H6
PDB IDs		7WWB	2NDJ 6V00 6V01
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Regulation Of Potassium Ion Export Across Plasma Membrane Basolateral Part Of Cell Negative Regulation Of Voltage-gated Potassium Channel Activity Intracellular Chloride Ion Homeostasis Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Export Across Plasma Membrane Paraspeckles Regulation Of Lymphoid Progenitor Cell Differentiation MRNA Cleavage Factor Complex Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Pro-B Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Alternative Polyadenylation Positive Regulation Of Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Protein Heterotetramerization Chloride Ion Homeostasis Membrane Repolarization During Action Potential Ventricular Cardiac Muscle Cell Action Potential Monoatomic Anion Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Stem Cell Differentiation Neuronal Cell Body Membrane Negative Regulation Of Transporter Activity Membrane Repolarization Protein Heterooligomerization MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of Potassium Ion Transport MRNA 3'-end Processing Regulation Of Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Cellular_component Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential
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