OTP and TPGS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTP	TPGS2
Description		orthopedia homeobox	tubulin polyglutamylase complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Nuclear Body	Cytoplasm Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Nervous System Development Neuroblast Proliferation Forebrain Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Cell Differentiation Neuron Differentiation Neuroendocrine Cell Differentiation Dopaminergic Neuron Differentiation	Microtubule Cytoskeleton Organization Microtubule Polymerization Cilium Disassembly
Pathways			Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		8 interacting genes: BEX1 CCL21 CDK6 CPNE7 EOMES PDE6D SLC12A7 TPGS2	3 interacting genes: EWSR1 OTP ZDHHC17
Entrez ID		23440	25941
HPRD ID		05166	12684
Ensembl ID		ENSG00000171540	ENSG00000134779
Uniprot IDs		Q5XKR4	A0A087WUC8 A0A087X1R7 K7EKC0 Q68CL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell-matrix Adhesion Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Negative Regulation Of Dendritic Cell Dendrite Assembly CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Cell-matrix Adhesion Stem Cell Differentiation Neurogenesis Positive Regulation Of Cell-substrate Adhesion Regulation Of Dendritic Cell Dendrite Assembly Mesodermal To Mesenchymal Transition Involved In Gastrulation	Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Neurohypophysis Development Protein-cysteine S-myristoyltransferase Activity Hypothalamus Cell Differentiation Protein-cysteine S-stearoyltransferase Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Neuroendocrine Cell Differentiation Protein Lipidation Positive Regulation Of Neuroblast Proliferation
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