TARDBP and LSM6

Number of citations of the paper that reports this interaction (PubMedID 24825905)
69

Data Source:
BioGRID (two hybrid)

		TARDBP	LSM6
Description		TAR DNA binding protein	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs			Uridine Uridine monophosphate Citric acid
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		19 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 FCGR2A IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	16 interacting genes: APP CEBPA LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP
Entrez ID		23435	11157
HPRD ID		05466	06286
Ensembl ID		ENSG00000120948	ENSG00000164167
Uniprot IDs		Q13148 Q9H256	P62312
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity	Lsm1-7-Pat1 Complex U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Spliceosomal Complex Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing Ribonucleoprotein Complex Precatalytic Spliceosome RNA Binding Catalytic Step 2 Spliceosome Macromolecule Metabolic Process Spliceosomal SnRNP Assembly MRNA Catabolic Process Nucleus U6 SnRNA Binding SMN-Sm Protein Complex RNA Catabolic Process Nucleoplasm U12-type Spliceosomal Complex P-body Spliceosomal Complex Assembly PICln-Sm Protein Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Poly(G) Binding Protein-RNA Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process U4 SnRNP Methylosome Negative Regulation Of Biosynthetic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly Small Nuclear Ribonucleoprotein Complex MRNA Methylguanosine-cap Decapping Nuclear-transcribed MRNA Catabolic Process U1 SnRNP U5 SnRNP RNA Decapping
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