ATP13A2 and OSTC

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	OSTC
Description		ATPase cation transporting 13A2	oligosaccharyltransferase complex non-catalytic subunit
Image
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		Ion transport by P-type ATPases	Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	7 interacting genes: ATP13A2 CCR9 EDA F2RL1 GPR35 LARP7 TRARG1
Entrez ID		23400	58505
HPRD ID		13677	13120
Ensembl ID		ENSG00000159363	ENSG00000198856
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	A0A087WUD3 Q9NRP0
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES	6S7O 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine Receptor Activity Cytokine-mediated Signaling Pathway Trachea Gland Development Proteinase-activated Receptor Activity Positive Regulation Of Exocytosis Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Protein Localization Positive Regulation Of Renin Secretion Into Blood Stream Chemokine-mediated Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Polyamine Transmembrane Transporter Activity Organelle Membrane Fusion Spermine Transport Extracellular Exosome Biogenesis Vesicle Fusion P-type Transmembrane Transporter Activity Spermine Transmembrane Transport Organelle Fusion ABC-type Polyamine Transporter Activity Box C/D Sno(s)RNA 3'-end Processing U6 2'-O-snRNA Methylation Death Receptor Agonist Activity Positive Regulation Of Protein Secretion Positive Regulation Of Killing Of Cells Of Another Organism Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Regulation Of Autophagosome Size Membrane Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Regulation Of Protein Localization To Nucleus Hair Follicle Placode Formation Salivary Gland Cavitation Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of Exocytosis SnRNA Modification Glucose Import In Response To Insulin Stimulus Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
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