UFL1 and ATP4A

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (two hybrid)

		UFL1	ATP4A
Description		UFM1 specific ligase 1	ATPase H+/K+ transporting subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection	Extracellular Space Plasma Membrane Potassium:proton Exchanging ATPase Complex Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity	Nucleotide Binding Magnesium Ion Binding P-type Sodium:potassium-exchanging Transporter Activity ATP Binding P-type Potassium Transmembrane Transporter Activity P-type Potassium:proton Transporter Activity ATP Hydrolysis Activity Potassium Ion Binding Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation	Monoatomic Ion Transport Potassium Ion Transport Intracellular Sodium Ion Homeostasis Response To Xenobiotic Stimulus Regulation Of Proton Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane PH Reduction Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ion transport by P-type ATPases
Drugs			Pantoprazole Omeprazole Lansoprazole Esomeprazole Rabeprazole Dexlansoprazole Vonoprazan
Diseases
GWAS		Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)	Platelet count ( 29403010)
Interacting Genes		17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219	2 interacting genes: CLK1 UFL1
Entrez ID		23376	495
HPRD ID		11109	00668
Ensembl ID		ENSG00000014123	ENSG00000105675
Uniprot IDs		O94874	A0A384MR29 P20648
PDB IDs		8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
Enriched GO Terms of Interacting Partners?			Protein K69-linked Ufmylation UFM1 Transferase Activity Regulation Of Reticulophagy Positive Regulation Of Reticulophagy UFM1 Ligase Activity Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Ufmylation Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Positive Regulation Of Glial Cell Proliferation Reticulophagy Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell DNA Double-strand Break Processing NLRP3 Inflammasome Complex Assembly Negative Regulation Of Immune Response To Tumor Cell Hematopoietic Stem Cell Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Response To Tumor Cell Negative Regulation Of T Cell Mediated Immunity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Canonical Inflammasome Complex Assembly Rescue Of Stalled Ribosome Regulation Of Intracellular Estrogen Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Glial Cell Proliferation Blood Circulation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Ribosome Disassembly DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Response To Endoplasmic Reticulum Stress
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