KHNYN and PLOD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KHNYN	PLOD3
Description		KH and NYN domain containing	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
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GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasmic Ribonucleoprotein Granule	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Molecular_function RNA Binding MRNA Binding RNA Endonuclease Activity Protein Binding	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity
	Biological Process	Biological_process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid
Diseases
GWAS		Appendicular lean mass ( 33097823)	Blood protein levels ( 30072576) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725)
Interacting Genes		6 interacting genes: CUL1 CUL2 HECTD1 PLOD3 TEPSIN UBC	20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620
Entrez ID		23351	8985
HPRD ID		11076	04347
Ensembl ID		ENSG00000100441	ENSG00000106397
Uniprot IDs		A8K6L5 O15037	O60568
PDB IDs		2N5M 2N7K 8WZC 9BGL 9CS9 9HTS	6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Scaffold Activity Modification-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Proteolysis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Coated Vesicle Membrane Ubiquitin-dependent Protein Catabolic Process Hydroxylysine Biosynthetic Process Protein Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Basement Membrane Assembly Procollagen Galactosyltransferase Activity Intrinsic Apoptotic Signaling Pathway Catabolic Process Epidermis Morphogenesis Protein-macromolecule Adaptor Activity Peptidyl-lysine Hydroxylation Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Endothelial Cell Morphogenesis Apoptotic Signaling Pathway Protein Tag Activity Protein Hydroxylation Cul2-RING Ubiquitin Ligase Complex L-ascorbic Acid Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Apoptotic Process Macromolecule Metabolic Process Small Molecule Binding Heart Valve Development
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