NEDD4L and SCNN1B

Number of citations of the paper that reports this interaction (PubMedID 18322022)
34

Data Source:
HPRD (in vitro, in vivo)

		NEDD4L	SCNN1B
Description		NEDD4 like E3 ubiquitin protein ligase	sodium channel epithelial 1 subunit beta
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Apical Plasma Membrane Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sodium Channel Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Monoatomic Ion Transport Neuromuscular Junction Development Protein Ubiquitination Cell Differentiation Neuron Projection Development Receptor Internalization Regulation Of Protein Stability Receptor Catabolic Process Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Regulation Of Membrane Repolarization Regulation Of Biological Quality Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Caveolin-mediated Endocytosis	Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Renal System Process Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Artery Smooth Muscle Contraction Response To Food Aldosterone Metabolic Process Erythrocyte Homeostasis Monoatomic Ion Transmembrane Transport Multicellular Organism Growth Sodium Ion Transmembrane Transport Epithelial Fluid Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Potassium Ion Homeostasis Sodium Ion Homeostasis Mucus Secretion Neutrophil-mediated Killing Of Bacterium Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels Sensory perception of salty taste
Drugs			Triamterene Amiloride
Diseases			Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874 33547301) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 33339817 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Manganese levels ( 26025379) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817 33547301)	Kidney stones ( 31729369)
Interacting Genes		151 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT1 AKT3 AMOT APEX2 ARHGDIA ARRB1 ARRB2 AURKC BBX BMPR1A CACNB1 CAMK1D CDC34 CDK3 CDK5 CEP55 CHLSN CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 FOXO1 GORAB GRIA1 H1-0 HAX1 HNRNPD HSPA5 IFRD2 IKBKB IL6ST KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP1LC3A MAP2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NEIL3 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 OGG1 PBX1 PDCD6IP PIP4P2 PRKX PRR16 PRRG1 PRRG2 PSMD4 PTGR3 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SLC9A3 SMAD2 SMAD3 SMAD7 SNCA SP1 SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRAF3 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 USP7 VDAC2 WBP2 WNK4 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1 ZC3HAV1L ZDHHC3	14 interacting genes: ANK3 CNTN1 COMMD10 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		23327	6338
HPRD ID		05903	02861
Ensembl ID		ENSG00000049759	ENSG00000168447
Uniprot IDs		A0A1B0GVY1 B7Z2P9 B7Z6K0 Q96PU5	B2R812 H3BQ95 P51168
PDB IDs		2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK 6ZBT 6ZC9 7LP1 7LP2 7LP3 7LP4 7LP5 7NMZ	6BQN 6WTH 9BLR 9BTG 9BTU
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Kinase Activity ATP Binding Protein Serine/threonine Kinase Activity Protein Modification Process Ubiquitin Protein Ligase Binding Kinase Activity Nucleotide Binding Protein Serine Kinase Activity Protein Phosphorylation Transferase Activity Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Protein Polyubiquitination Protein Metabolic Process Regulation Of Signaling Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cytoplasm Regulation Of Transport Protein Autophosphorylation Cellular Response To Oxygen-containing Compound Protein Domain Specific Binding Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Transmembrane Transporter Binding Protein K11-linked Ubiquitination Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication TORC1 Signaling Protein Sequestering Activity Macromolecule Catabolic Process Nucleus Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Potassium Channel Regulator Activity Regulation Of Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Signal Transduction	Negative Regulation Of Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Transport Import Into Cell Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Response To Aldosterone Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Acidic PH Regulation Of Potassium Ion Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Response To Acidic PH Ubiquitin-protein Transferase Activity Cellular Response To PH Negative Regulation Of Transmembrane Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Neuromuscular Junction Development Response To Mineralocorticoid Sodium Ion Transmembrane Transport Response To PH Import Across Plasma Membrane Regulation Of Metal Ion Transport Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Monoubiquitination Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Sodium Channel Inhibitor Activity Regulation Of Dendrite Morphogenesis Endocytosis Cellular Response To Corticosteroid Stimulus Receptor Internalization Protein K63-linked Ubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?