ACSL6 and PCDHB5

		ACSL6	PCDHB5
Description		acyl-CoA synthetase long chain family member 6	protocadherin beta 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Plasma Membrane Membrane Synapse
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Chemical Synaptic Transmission Nervous System Development Synapse Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Refractive error ( 32231278)
Interacting Genes		12 interacting genes: ARHGAP26 GATM HGD KLHL3 NRSN1 PCDHB5 PCMTD2 PHYH POLR2L SEPTIN8 TCERG1 ZNF655	4 interacting genes: ACSL6 GRB2 PIK3R3 RB1
Entrez ID		23305	26167
HPRD ID		09190	07560
Ensembl ID		ENSG00000164398	ENSG00000113209
Uniprot IDs		A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0	Q59FR6 Q9Y5E4
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity	Phosphotyrosine Residue Binding Insulin Receptor Signaling Pathway Ras Protein Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Negative Regulation Of Defense Response Grb2-EGFR Complex T Cell Activation Neurotrophin TRKA Receptor Binding Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Chromatin Lock Complex Importin-alpha Family Protein Binding Positive Regulation Of Collagen Fibril Organization 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Branching Involved In Labyrinthine Layer Morphogenesis 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Arachidonate-CoA Ligase Activity Schwann Cell Development Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Insulin Receptor Substrate Binding Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Enzyme Binding Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Hepatocyte Apoptotic Process Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Anoikis Long-chain Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty Acid-CoA Ligase Activity
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