MGRN1 and UBE2T

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		MGRN1	UBE2T
Description		mahogunin ring finger 1	ubiquitin conjugating enzyme E2 T
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Smoothened Signaling Pathway Heart Development Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Protein Polyubiquitination DNA Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Milk allergy (maternal genetic effects) ( 29489655) Triglyceride levels ( 32154731)	Breast cancer ( 23535733) Celiac disease ( 23936387)
Interacting Genes		13 interacting genes: AMFR TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W	25 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF167 RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6 UBC ZNRF2
Entrez ID		23295	29089
HPRD ID		07397	13704
Ensembl ID		ENSG00000102858	ENSG00000077152
Uniprot IDs		O60291	Q9NPD8
PDB IDs			1YH2 4CCG 5NGZ 5OJJ 6R75 7KZR 7KZS 7KZT 7KZV 8JUC 8JVD 8JVE 8JVL
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Modification Process Transferase Activity Catabolic Process ATP Binding Protein K6-linked Ubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination Nucleotide Binding Protein Monoubiquitination Protein Autoubiquitination Protein K27-linked Ubiquitination Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K29-linked Ubiquitination ERAD Pathway Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Establishment Of Protein Localization Regulation Of Protein Targeting To Mitochondrion Cellular Response To Stress Response To Endoplasmic Reticulum Stress SUMO Conjugating Enzyme Activity Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Establishment Of Protein Localization TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex RING-like Zinc Finger Domain Binding Regulation Of TORC1 Signaling	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Transferase Activity Protein Polyubiquitination Protein Metabolic Process Zinc Ion Binding Metal Ion Binding Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Autoubiquitination Protein K6-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Response To Stress Cellular Response To Stress Protein K27-linked Ubiquitination Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytosol Ubiquitin Activating Enzyme Activity DNA Damage Response DNA Damage Checkpoint Signaling Ubiquitin Conjugating Enzyme Binding Condensed Chromosome Negative Regulation Of Programmed Cell Death Regulation Of Organelle Organization Catabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Protein Monoubiquitination Cytoplasm Ubiquitin-like Modifier Activating Enzyme Activity Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Autophagy Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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