PPIP5K2 and SMARCC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIP5K2	SMARCC1
Description		diphosphoinositol pentakisphosphate kinase 2	SWI/SNF related BAF chromatin remodeling complex subunit C1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Kinetochore Chromatin Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex
	Molecular Function	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity 5-diphosphoinositol Pentakisphosphate 1-kinase Activity Inositol Hexakisphosphate 1-kinase Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Inositol Metabolic Process Sensory Perception Of Sound Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Regulation Of Mitotic Metaphase/anaphase Transition Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Synthesis of pyrophosphates in the cytosol	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Insulinogenic index ( 23263489) Intelligence (MTAG) ( 29326435) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first birth ( 34211149) Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: POU2F1 POU6F2 SMARCC1	54 interacting genes: ADAMTSL4 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 SREBF1 STT3B TAF15 TRIM42 UFSP1 USP7 VGLL3 ZNF581
Entrez ID		23262	6599
HPRD ID		13802	03435
Ensembl ID		ENSG00000145725	ENSG00000173473
Uniprot IDs		A0A087WZV0 A0A8V8TMN4 B4DGV1 O43314	Q58EY4 Q92922
PDB IDs		3T54 3T7A 3T99 3T9A 3T9B 3T9C 3T9D 3T9E 3T9F 4HN2 4NZM 4NZN 4NZO 4Q4C 4Q4D 5BYA 5BYB 5DGH 5DGI 6N5C 8G9E	2YUS 5GJK 6KZ7 6YXO 6YXP
Enriched GO Terms of Interacting Partners?		Chromatin	Intermediate Filament Transcription Coregulator Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus Rhythmic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Factor Activity Protein-DNA Complex Disassembly Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Ketone Identical Protein Binding Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Nuclear Receptor-mediated Corticosteroid Signaling Pathway DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament Cellular Response To Peptide Hormone Stimulus Regulation Of Primary Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Alpha-beta T Cell Activation Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Innate Immune Response Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Defense Response Regulation Of Signal Transduction By P53 Class Mediator Protein K29-linked Ubiquitination Progesterone Receptor Signaling Pathway Response To Hormone Transcription Coregulator Activity
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