FLT4 and VEGFC

Number of citations of the paper that reports this interaction (PubMedID 8700872)
52

Data Source:
HPRD (in vivo)

		FLT4	VEGFC
Description		fms related receptor tyrosine kinase 4	vascular endothelial growth factor C
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity	Protein Binding Growth Factor Activity Chemoattractant Activity Vascular Endothelial Growth Factor Receptor 3 Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Substrate-dependent Cell Migration Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Animal Organ Morphogenesis Glial Cell Proliferation Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Mast Cell Chemotaxis Positive Regulation Of Lymphangiogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor
Pathways		VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Tivozanib Fostamatinib Selpercatinib
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)	Gastric cancer
GWAS		Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)	Blood protein levels ( 30072576) Chin dimples ( 27182965) HIV-1 viral setpoint ( 22174851) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Mastocytosis (KIT D816V positive) ( 33421400) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		20 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 GRIA1 HNRNPH1 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 NKX2-5 PNPLA8 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD	3 interacting genes: FLT4 KDR SGTB
Entrez ID		2324	7424
HPRD ID		00636	03317
Ensembl ID		ENSG00000037280	ENSG00000150630
Uniprot IDs		E9PD35 P35916	P49767
PDB IDs		4BSJ 4BSK	2X1W 2X1X 4BSK 6TJT
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Angiogenesis Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Vascular Endothelial Growth Factor Signaling Pathway Receptor Internalization Integrin Alpha5-beta1 Complex Negative Regulation Of Anoikis Regulation Of Vasculature Development Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Positive Chemotaxis Regulation Of Anoikis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Integrin-mediated Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Mast Cell Chemotaxis Neurotrophin TRKA Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Chemotaxis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Integrin Binding Response To Growth Factor Peptidyl-tyrosine Phosphorylation Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Migration Developmental Process	Vascular Endothelial Growth Factor Receptor Activity Lymph Vessel Development Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Growth Factor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Lung Alveolus Development Vasculature Development Positive Regulation Of Endothelial Cell Proliferation Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Protein Tyrosine Kinase Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade TRC Complex Positive Regulation Of Protein Phosphorylation Cellular Response To Hydrogen Sulfide Positive Regulation Of Phosphorylation Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Tube Morphogenesis Positive Regulation Of Phosphate Metabolic Process Angiogenesis Response To Growth Factor Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sorting Endosome Endocardium Development Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Protein Phosphorylation Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Post-embryonic Eye Morphogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Phosphorylation Regulation Of Protein Phosphorylation Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Bone Development Regulation Of Phosphorylation
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