SIK2 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SIK2	GABARAPL2
Description		salt inducible kinase 2	GABA type A receptor associated protein like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Protein Phosphorylation Lipid Biosynthetic Process Intracellular Signal Transduction ERAD Pathway Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Macroautophagy TBC/RABGAPs
Drugs		Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 34103634 30929738 31361310 31619474 32296059) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		8 interacting genes: APP CRTC2 CRTC3 EP300 FBXW7 GABARAPL2 HDAC5 IRS1	105 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPM6A GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PRKAR2A PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		23235	11345
HPRD ID		12348	16246
Ensembl ID		ENSG00000170145	ENSG00000034713
Uniprot IDs		Q9H0K1	P60520
PDB IDs			4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxygen-containing Compound Cellular Response To CAMP Positive Regulation Of Transcription By RNA Polymerase II Protein Tetramerization Response To CAMP CAMP Response Element Binding Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Response To Purine-containing Compound Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Insulin Receptor Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Leukocyte Activation Protein Homooligomerization Positive Regulation Of Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Macromolecule Metabolic Process Homeostatic Process Cell Activation Protein Complex Oligomerization Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Protein Kinase C Binding Protein-containing Complex Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Gluconeogenesis Transcription Coactivator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Myeloid Cell Development Chemical Homeostasis Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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