PMPCA and PMPCB

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, cross-linking study)
HPRD (in vitro)

		PMPCA	PMPCB
Description		peptidase, mitochondrial processing subunit alpha	peptidase, mitochondrial processing subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Processing Peptidase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Processing Peptidase Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Protein Processing	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport
Pathways		Mitochondrial protein import Processing of SMDT1 Mitochondrial protein degradation	Mitochondrial protein import Processing of SMDT1
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) LDL cholesterol levels ( 32203549) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		16 interacting genes: ASS1 AVEN BMPR2 KIF2C LINC01554 NDOR1 NPSR1 NSMF OGT OLFM1 PCDHB4 PMPCB SCUBE1 SKIC2 UBAC1 ZNF76	10 interacting genes: AP4M1 ARPC1B FXN MARK3 NPSR1 PMPCA PTGER4 VGF ZNF3 ZNHIT1
Entrez ID		23203	9512
HPRD ID		07500	07539
Ensembl ID		ENSG00000165688	ENSG00000105819
Uniprot IDs		Q10713 Q5SXN9	A0A9L9PXG6 A0A9L9PXH0 A0A9L9PXI7 B3KM34 G3V0E4 O75439 Q96CP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse
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