GANAB and PRRC2A

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		GANAB	PRRC2A
Description		glucosidase II alpha subunit	proline rich coiled-coil 2A
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Alpha-glucosidase Activity Glc2Man9GlcNAc2 Oligosaccharide Glucosidase Activity	RNA Binding Protein Binding
	Biological Process	Carbohydrate Metabolic Process N-glycan Processing	Cell Differentiation
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs		Miglitol
Diseases
GWAS		A body shape index ( 34021172) Hip index ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 34211149) Anxiety ( 33859377) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Childhood body mass index ( 33045005) Hand grip strength ( 29691431) Height ( 28552196) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Malaria ( 31844061) Menopause (age at onset) ( 22267201) Metabolite levels ( 31628463) Platelet distribution width ( 32888494) Schizophrenia ( 23894747) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908) Waist circumference ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: AURKB CCNH CREB3L4 CSNK2A1 LINC01554 MAPK8 PRKCSH PRRC2A PTPRC RAP1A RNF10	32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L
Entrez ID		23193	7916
HPRD ID		03516	00807
Ensembl ID		ENSG00000089597	ENSG00000204469
Uniprot IDs		B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697	A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634
PDB IDs		8D43 8EMR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Localization To Chromosome Protein Localization To Site Of Double-strand Break	Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription
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