FLNC and RPS6KA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FLNC	RPS6KA2
Description		filamin C	ribosomal protein S6 kinase A2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Synapse Meiotic Spindle
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus
Pathways		Cell-extracellular matrix interactions	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Café-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 23128233 27569725) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	19 interacting genes: AFDN BAD CREB1 DYNLT1 DYNLT2 FLNC FOS JUN KCNJ6 L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 OTUD4 SHANK1 TBXT THBS2 TP53
Entrez ID		2318	6196
HPRD ID		00018	03403
Ensembl ID		ENSG00000128591	ENSG00000071242
Uniprot IDs		Q14315 Q59H94	B7Z3B5 F2Z2J1 Q15349 X5D337
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication	Regulation Of Golgi Inheritance Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Face Development Schwann Cell Development Animal Organ Formation ERBB2 Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Lung Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Regulation Of Stress-activated MAPK Cascade Cell Differentiation Gland Development Anatomical Structure Morphogenesis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cellular Component Organization Response To Lipid Cell Surface Receptor Signaling Pathway Response To Nicotine Transcription Factor AP-1 Complex Regulation Of Cell Development Thymus Development Intracellular Signaling Cassette Cardiac Neural Crest Cell Development Involved In Heart Development Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Positive Regulation Of MiRNA Transcription Outer Ear Morphogenesis Identical Protein Binding Cellular Response To Starvation Positive Regulation Of MiRNA Metabolic Process Glial Cell Development Response To Mechanical Stimulus
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