ABRAXAS2 and THAP5

Number of citations of the paper that reports this interaction (PubMedID 21195082)
46

Data Source:
BioGRID (two hybrid)

		ABRAXAS2	THAP5
Description		abraxas 2, BRISC complex subunit	THAP domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Midbody Spindle Pole Centrosome Ciliary Basal Body Microtubule Minus-end BRISC Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding	Protease Binding DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle
Pathways		Metalloprotease DUBs
Drugs
Diseases
GWAS		Bone mineral content ( 31790847)	JT interval (sulfonylurea treatment interaction) ( 27958378) Smoking behavior ( 22006218)
Interacting Genes		8 interacting genes: ATE1 DCUN1D1 NUMA1 OGT SMURF2 THAP5 UBC USP7	2 interacting genes: ABRAXAS2 SKIL
Entrez ID		23172	168451
HPRD ID		13783	15498
Ensembl ID		ENSG00000165660	ENSG00000177683
Uniprot IDs		Q15018	Q7Z6K1
PDB IDs		6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Protein Ubiquitination Cortical Microtubule Anastral Spindle Assembly Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Nucleus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Mitotic Spindle Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Arginyl-tRNA--protein Transferase Activity Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Protein Localization To Vacuole Lateral Cell Cortex Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Protein Arginylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway Cell Cortex Region Regulation Of Cellular Localization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Mitotic Spindle Astral Microtubule Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Microtubule Bundle Regulation Of Protein Localization To Cell Periphery Regulation Of TOR Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Ubiquitin-like Protein Binding
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